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	[[Category:Proteins]]		[[Category:Proteins]]
	[[Category:Corneal dystrophies]]		[[Category:Corneal dystrophies]]
			== TGFBI ==
			<gallery>
			File:Mutated_transforming_growth_factor_beta_induced_protein_in_the_superficial_corneal_stroma.jpg\|Mutated transforming growth factor beta induced protein in the superficial corneal stroma
			</gallery>

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	~~'''~~TGFBI~~''' (Transforming Growth Factor Beta Induced) is a [[protein]] that in humans is encoded by the TGFBI [[~~gene~~]]. This protein plays a crucial~~ role in ~~[[cell adhesion]] and [[cell migration]], and is involved in various cellular processes such as [[apoptosis]], [[cell proliferation]], and [[cell differentiation]].~~		{{Short description\|Overview of TGFBI gene and its role in human health}}

	== ~~Function~~ ==		==Overview==
	TGFBI ~~protein~~ is a ~~secreted protein~~ that ~~binds to [[collagen]], [[fibronectin]], and [[laminin]] and plays~~ a ~~role~~ in cell-collagen interactions. ~~The~~ protein is induced by [[transforming growth factor-beta]] (TGF-~~beta~~) ~~and acts to inhibit cell adhesion and migration. It is also thought to play~~ a role in the ~~[[extracellular matrix]]~~ and ~~in the development of the [[cornea]]~~.		'''TGFBI''' (Transforming Growth Factor Beta Induced) is a gene that encodes a protein involved in cell-collagen interactions. This protein is crucial for various cellular processes, including cell adhesion, migration, and proliferation. TGFBI is induced by [[transforming growth factor beta]] (TGF-_), a cytokine that plays a significant role in regulating the immune system and maintaining tissue homeostasis.

	== ~~Clinical significance~~ ==		==Structure and Function==
	~~Mutations in the~~ TGFBI gene ~~are associated with~~ several [[~~corneal dystrophies~~]], ~~including~~ [[~~granular corneal dystrophy type 1~~]], [[~~lattice corneal dystrophy type 1~~]], and ~~[[Avellino corneal dystrophy]]. These conditions are characterized by the accumulation of abnormal TGFBI protein in the cornea, leading to vision loss~~.		The TGFBI gene is located on chromosome 5q31 and encodes a protein known as TGFBIp or keratoepithelin. This protein contains several [[Fas1 domains]], which are responsible for its interaction with [[collagen]] and other extracellular matrix components. TGFBIp is secreted into the extracellular matrix, where it binds to [[integrins]] and influences cell behavior.

	== ~~Research~~ ==		===Role in Cell Adhesion===
	~~Research into TGFBI has focused~~ on ~~its role in~~ cell ~~adhesion~~ and ~~migration,~~ as ~~well as its potential role in cancer~~. ~~Some studies suggest that TGFBI may act as a [[tumor suppressor gene]]~~, ~~inhibiting~~ the ~~growth~~ and ~~spread of cancer cells~~.		TGFBIp facilitates cell adhesion by interacting with integrins on the cell surface. This interaction is essential for maintaining the structural integrity of tissues and for processes such as wound healing. By binding to collagen, TGFBIp helps anchor cells to the extracellular matrix, providing stability and support.

	== ~~See also~~ ==		===Role in Cell Migration===
			In addition to its role in adhesion, TGFBIp is involved in cell migration. It modulates the movement of cells by altering the extracellular matrix and influencing integrin signaling pathways. This function is particularly important during embryonic development and tissue repair.

			==Clinical Significance==
			Mutations in the TGFBI gene are associated with several [[corneal dystrophies]], including [[granular corneal dystrophy]] and [[lattice corneal dystrophy]]. These conditions are characterized by the accumulation of protein deposits in the cornea, leading to vision impairment.

			===Granular Corneal Dystrophy===
			Granular corneal dystrophy is caused by specific mutations in the TGFBI gene, leading to the formation of granular deposits in the corneal stroma. These deposits interfere with light transmission, resulting in decreased visual acuity.

			===Lattice Corneal Dystrophy===
			Lattice corneal dystrophy is another condition linked to TGFBI mutations. It is characterized by the presence of amyloid deposits in the cornea, which form a lattice-like pattern. This condition can cause recurrent corneal erosions and vision loss.

			==Research and Therapeutic Implications==
			Understanding the role of TGFBI in cell-matrix interactions has implications for developing therapies for corneal dystrophies and other conditions involving abnormal cell adhesion and migration. Research is ongoing to explore potential treatments that target the pathways influenced by TGFBI.

			==Related Pages==
	* [[Transforming growth factor beta]]		* [[Transforming growth factor beta]]
	* [[Corneal dystrophy]]		* [[Corneal dystrophy]]
	* [[~~Cell adhesion~~]]		* [[Integrin]]
	* [[~~Cell migration~~]]		* [[Extracellular matrix]]

	~~== References ==~~		[[Category:Genes on human chromosome 5]]
	~~<references />~~

	[[Category:Genes]]
	[[Category:Proteins]]		[[Category:Proteins]]
	[[Category:~~Cell biology~~]]		[[Category:Corneal dystrophies]]
	~~[[Category:Ophthalmology]]~~
	~~[[Category:Medicine]]~~

	~~{{medicine-stub}}~~
	~~<gallery>~~
	~~File:TGFBI_Mutated_transforming_growth_factor_beta_induced_protein_in_the_superficial_corneal_stroma.jpg\|TGFBI Mutated transforming growth factor beta induced protein in the superficial corneal stroma~~
	~~</gallery>~~

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	{{medicine-stub}}		{{medicine-stub}}
			<gallery>
			File:TGFBI_Mutated_transforming_growth_factor_beta_induced_protein_in_the_superficial_corneal_stroma.jpg\|TGFBI Mutated transforming growth factor beta induced protein in the superficial corneal stroma
			</gallery>

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'''TGFBI''' (Transforming Growth Factor Beta Induced) is a [[protein]] that in humans is encoded by the TGFBI [[gene]]. This protein plays a crucial role in [[cell adhesion]] and [[cell migration]], and is involved in various cellular processes such as [[apoptosis]], [[cell proliferation]], and [[cell differentiation]].

== Function ==
TGFBI protein is a secreted protein that binds to [[collagen]], [[fibronectin]], and [[laminin]] and plays a role in cell-collagen interactions. The protein is induced by [[transforming growth factor-beta]] (TGF-beta) and acts to inhibit cell adhesion and migration. It is also thought to play a role in the [[extracellular matrix]] and in the development of the [[cornea]].

== Clinical significance ==
Mutations in the TGFBI gene are associated with several [[corneal dystrophies]], including [[granular corneal dystrophy type 1]], [[lattice corneal dystrophy type 1]], and [[Avellino corneal dystrophy]]. These conditions are characterized by the accumulation of abnormal TGFBI protein in the cornea, leading to vision loss.

== Research ==
Research into TGFBI has focused on its role in cell adhesion and migration, as well as its potential role in cancer. Some studies suggest that TGFBI may act as a [[tumor suppressor gene]], inhibiting the growth and spread of cancer cells.

== See also ==
* [[Transforming growth factor beta]]
* [[Corneal dystrophy]]
* [[Cell adhesion]]
* [[Cell migration]]

== References ==
<references />

[[Category:Genes]]
[[Category:Proteins]]
[[Category:Cell biology]]
[[Category:Ophthalmology]]
[[Category:Medicine]]

{{medicine-stub}}

TGFBI - Revision history

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