https://wikimd.org/index.php?action=history&feed=atom&title=TAR_DNA-binding_protein_43TAR DNA-binding protein 43 - Revision history2026-04-27T02:31:08ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=TAR_DNA-binding_protein_43&diff=5895552&oldid=prevPrab: CSV import2024-06-10T13:41:41Z<p>CSV import</p>
<p><b>New page</b></p><div>[[File:Protein_TARDBP_PDB_1wf0.png|thumb|Protein TARDBP PDB 1wf0]] {{Short description|Protein involved in various cellular processes}}<br />
{{Infobox protein<br />
| name = TAR DNA-binding protein 43<br />
| image = <br />
| caption = <br />
| symbol = TARDBP<br />
| hgncid = 11588<br />
| chromosomal_location = 1p36.22<br />
| uniprot = Q13148<br />
}}<br />
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'''TAR DNA-binding protein 43''' ('''TDP-43''') is a protein that in humans is encoded by the '''TARDBP''' gene. TDP-43 is involved in various cellular processes, including [[transcription]], [[RNA splicing]], and [[mRNA]] stability. It is predominantly located in the [[nucleus]] but can also be found in the [[cytoplasm]] under certain conditions.<br />
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== Function ==<br />
TDP-43 is a highly conserved and ubiquitously expressed protein that binds to both [[DNA]] and [[RNA]]. It plays a crucial role in the regulation of gene expression by binding to specific sequences in the [[DNA]] and [[RNA]]. TDP-43 is involved in the processing of [[pre-mRNA]] and the regulation of [[mRNA]] stability and transport.<br />
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== Clinical Significance ==<br />
TDP-43 has been implicated in several [[neurodegenerative diseases]], including [[amyotrophic lateral sclerosis]] (ALS) and [[frontotemporal lobar degeneration]] (FTLD). In these diseases, TDP-43 is often found to be abnormally phosphorylated, ubiquitinated, and cleaved, leading to the formation of cytoplasmic inclusions. These inclusions are a hallmark of the pathology of these diseases.<br />
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== Structure ==<br />
TDP-43 contains two RNA recognition motifs (RRMs) that allow it to bind to RNA. It also has a glycine-rich C-terminal region that is involved in protein-protein interactions. The protein can form aggregates under pathological conditions, which are thought to contribute to the disease process in ALS and FTLD.<br />
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== Research ==<br />
Ongoing research is focused on understanding the exact mechanisms by which TDP-43 contributes to neurodegeneration. Studies are also exploring potential therapeutic strategies to prevent or reverse the pathological aggregation of TDP-43.<br />
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== See Also ==<br />
* [[Amyotrophic lateral sclerosis]]<br />
* [[Frontotemporal lobar degeneration]]<br />
* [[RNA splicing]]<br />
* [[Gene expression]]<br />
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== References ==<br />
{{Reflist}}<br />
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[[Category:Proteins]]<br />
[[Category:Neurodegenerative disorders]]<br />
[[Category:RNA-binding proteins]]<br />
[[Category:Human proteins]]<br />
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