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TAP2 - Revision history
2026-04-08T21:32:58Z
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2025-03-18T02:51:21Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 02:51, 18 March 2025</td>
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2025-02-11T05:45:35Z
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<p><b>New page</b></p><div>'''TAP2''' is a [[protein]] that in humans is encoded by the ''TAP2'' [[gene]]. The protein encoded by this gene is involved in the [[antigen processing]] pathway of the [[immune system]]. It is located in the [[endoplasmic reticulum]], where it functions to transport peptides from the cytoplasm into the endoplasmic reticulum, a critical step in the immune response to [[pathogens]].<br />
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== Function ==<br />
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The ''TAP2'' gene, along with the ''[[TAP1]]'' gene, encodes a protein that is a member of the [[ABC transporter]] superfamily. These proteins function to transport various molecules across extra- and intra-cellular membranes. The ''TAP1'' and ''TAP2'' proteins form a heterodimer that is involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum. This process is essential for the presentation of antigens to the immune system.<br />
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== Clinical significance ==<br />
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Mutations in the ''TAP2'' gene have been associated with various [[autoimmune diseases]], including [[ankylosing spondylitis]], [[type 1 diabetes]], and [[coeliac disease]]. Additionally, variations in this gene may influence susceptibility to [[viral infections]], including [[HIV]] and [[hepatitis C]].<br />
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== See also ==<br />
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* [[TAP1]]<br />
* [[ABC transporter]]<br />
* [[Antigen presentation]]<br />
* [[Endoplasmic reticulum]]<br />
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== References ==<br />
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<references /><br />
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[[Category:Genes]]<br />
[[Category:Proteins]]<br />
[[Category:Immunology]]<br />
[[Category:Medicine]]<br />
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{{medicine-stub}}</div>
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