https://wikimd.org/index.php?action=history&feed=atom&title=SulfanilamideSulfanilamide - Revision history2026-04-27T00:03:34ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Sulfanilamide&diff=6313454&oldid=prevPrab: CSV import2025-02-18T01:57:26Z<p>CSV import</p>
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</table>Prabhttps://wikimd.org/index.php?title=Sulfanilamide&diff=5288544&oldid=prevPrab: CSV import2024-02-25T13:04:42Z<p>CSV import</p>
<p><b>New page</b></p><div>'''Sulfanilamide''' is a [[sulfonamide]] [[antibacterial]] medication. It was one of the first systematic antibiotics to be used and was widely used in the second half of the 20th century. It is an intermediate in the synthesis of other pharmaceutical drugs such as [[sulfamethoxazole]] and [[sulfapyridine]].<br />
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== History ==<br />
Sulfanilamide was first synthesized by the Austrian chemist [[Paul Gelmo]] in 1908 and was used in the dye industry. Its antibacterial properties were discovered by the German pathologist and bacteriologist [[Gerhard Domagk]]. He was awarded the [[Nobel Prize in Physiology or Medicine]] in 1939 for the discovery of the antibacterial effects of [[Prontosil]], a red dye which is metabolized in the body to release sulfanilamide.<br />
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== Mechanism of action ==<br />
Sulfanilamide works by inhibiting the enzyme [[dihydropteroate synthase]]. This enzyme is needed in the synthesis of [[folic acid]], which is essential for the growth and multiplication of bacteria. By inhibiting this enzyme, sulfanilamide prevents the bacteria from synthesizing folic acid, thereby stopping their growth.<br />
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== Side effects ==<br />
Like all medications, sulfanilamide can cause side effects. These can include [[nausea]], [[vomiting]], [[diarrhea]], and [[allergic reactions]]. In rare cases, it can cause serious side effects such as [[Stevens-Johnson syndrome]], a severe skin reaction, and [[hemolytic anemia]], a condition in which red blood cells are destroyed faster than they can be made.<br />
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== See also ==<br />
* [[Sulfonamide (medicine)]]<br />
* [[Antibacterial]]<br />
* [[Paul Gelmo]]<br />
* [[Gerhard Domagk]]<br />
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[[Category:Antibiotics]]<br />
[[Category:Sulfonamides]]<br />
[[Category:Medicine]]<br />
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