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 '''Sudden Unexpected Death in Epilepsy''' (SUDEP) represents a severe and lethal complication linked with epilepsy.
 == Definition ==
 SUDEP is defined as the sudden, unexpected, non-traumatic, and non-drowning death in individuals diagnosed with epilepsy, in the absence of a detectable toxicological or anatomical cause of death following post-mortem examination<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712972/|title=Defining the risk of sudden unexpected death in epilepsy|website=National Institutes of Health|access-date=2023-06-21}}</ref>.
 == Epidemiology ==
 SUDEP affects approximately 1 in 1,000 adults and 1 in 4,500 children with epilepsy annually. It's important to note that these statistics may vary based on the severity and type of epilepsy, as well as other risk factors like poor medication adherence and generalized tonic-clonic seizures<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983615/|title=Risk Factors for SUDEP: A Controlled Prospective Cohort Study|website=National Institutes of Health|access-date=2023-06-21}}</ref>.
 == Differential Diagnosis ==
 Deaths resulting from prolonged seizure episodes, known as [[status epilepticus]], are not classified under SUDEP. Instead, these fatalities are regarded as a direct consequence of the severe prolonged seizure<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803790/|title=Status epilepticus and sudden unexpected death in epilepsy|website=National Institutes of Health|access-date=2023-06-21}}</ref>.
 == Mechanisms and Risk Factors ==
 The precise mechanisms underlying SUDEP remain incompletely understood, although disturbances in cardiac, respiratory, and autonomic functions during and after seizures are thought to play significant roles<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382713/|title=The Mechanisms of Sudden Unexpected Death in Epilepsy|website=National Institutes of Health|access-date=2023-06-21}}</ref>.
 == References ==
 <references />

Prab at 16:33, 21 June 2023

2023-06-21T16:33:22Z

New page

'''Sudden Unexpected Death in Epilepsy''' (SUDEP) represents a severe and lethal complication linked with epilepsy.

== Definition ==

SUDEP is defined as the sudden, unexpected, non-traumatic, and non-drowning death in individuals diagnosed with epilepsy, in the absence of a detectable toxicological or anatomical cause of death following post-mortem examination<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712972/|title=Defining the risk of sudden unexpected death in epilepsy|website=National Institutes of Health|access-date=2023-06-21}}</ref>.

== Epidemiology ==

SUDEP affects approximately 1 in 1,000 adults and 1 in 4,500 children with epilepsy annually. It's important to note that these statistics may vary based on the severity and type of epilepsy, as well as other risk factors like poor medication adherence and generalized tonic-clonic seizures<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983615/|title=Risk Factors for SUDEP: A Controlled Prospective Cohort Study|website=National Institutes of Health|access-date=2023-06-21}}</ref>.

== Differential Diagnosis ==

Deaths resulting from prolonged seizure episodes, known as [[status epilepticus]], are not classified under SUDEP. Instead, these fatalities are regarded as a direct consequence of the severe prolonged seizure<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803790/|title=Status epilepticus and sudden unexpected death in epilepsy|website=National Institutes of Health|access-date=2023-06-21}}</ref>.

== Mechanisms and Risk Factors ==

The precise mechanisms underlying SUDEP remain incompletely understood, although disturbances in cardiac, respiratory, and autonomic functions during and after seizures are thought to play significant roles<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382713/|title=The Mechanisms of Sudden Unexpected Death in Epilepsy|website=National Institutes of Health|access-date=2023-06-21}}</ref>.

== References ==
<references />
{{stub}}
[[Category:Epilepsy]]
[[Category:Neurological disorders]]
[[Category:Medical emergencies]]
[[Category:Death]]

Sudden unexpected death in epilepsy - Revision history

Prab: CSV import

Prab at 16:33, 21 June 2023