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			{{Infobox medical condition
			\| name = Subcutaneous T-cell lymphoma
			\| synonyms = Subcutaneous panniculitis-like T-cell lymphoma
			\| field = [[Hematology]], [[Oncology]]
			\| symptoms = [[Fever]], [[weight loss]], [[fatigue]], [[skin lesions]]
			\| complications = [[Hemophagocytic lymphohistiocytosis]]
			\| onset = Typically in [[adulthood]]
			\| duration = Chronic
			\| causes = Unknown
			\| risks = Possible [[genetic predisposition]]
			\| diagnosis = [[Biopsy]], [[immunohistochemistry]], [[molecular testing]]
			\| differential = [[Lupus panniculitis]], [[infectious panniculitis]], [[cutaneous T-cell lymphoma]]
			\| treatment = [[Chemotherapy]], [[radiation therapy]], [[immunotherapy]]
			\| prognosis = Variable, depends on response to treatment
			\| frequency = Rare
			}}
	[[file:PTCL-subtypes.jpg\|thumb\|left]] '''Subcutaneous T-cell lymphoma''' (STCL) is a rare type of [[cutaneous T-cell lymphoma]] (CTCL) that primarily affects the subcutaneous tissue, which is the layer of fat and connective tissue beneath the skin. This form of lymphoma is characterized by the presence of malignant T-cells in the subcutaneous tissue, leading to various clinical manifestations.		[[file:PTCL-subtypes.jpg\|thumb\|left]] '''Subcutaneous T-cell lymphoma''' (STCL) is a rare type of [[cutaneous T-cell lymphoma]] (CTCL) that primarily affects the subcutaneous tissue, which is the layer of fat and connective tissue beneath the skin. This form of lymphoma is characterized by the presence of malignant T-cells in the subcutaneous tissue, leading to various clinical manifestations.

	== Clinical Presentation ==		== Clinical Presentation ==
	Patients with subcutaneous T-cell lymphoma typically present with [[nodules]], [[plaques]], or [[tumors]] in the subcutaneous tissue. These lesions can be painful and may be accompanied by systemic symptoms such as [[fever]], [[weight loss]], and [[fatigue]]. The skin overlying the affected areas may appear normal or show signs of [[erythema]] and [[ulceration]].		Patients with subcutaneous T-cell lymphoma typically present with [[nodules]], [[plaques]], or [[tumors]] in the subcutaneous tissue. These lesions can be painful and may be accompanied by systemic symptoms such as [[fever]], [[weight loss]], and [[fatigue]]. The skin overlying the affected areas may appear normal or show signs of [[erythema]] and [[ulceration]].

	== Diagnosis ==		== Diagnosis ==
	The diagnosis of subcutaneous T-cell lymphoma involves a combination of clinical evaluation, imaging studies, and histopathological examination. A [[biopsy]] of the affected tissue is essential for confirming the diagnosis. Histologically, STCL is characterized by the infiltration of atypical T-cells in the subcutaneous fat. Immunohistochemical staining and molecular studies are often performed to identify specific markers and genetic abnormalities associated with the disease.		The diagnosis of subcutaneous T-cell lymphoma involves a combination of clinical evaluation, imaging studies, and histopathological examination. A [[biopsy]] of the affected tissue is essential for confirming the diagnosis. Histologically, STCL is characterized by the infiltration of atypical T-cells in the subcutaneous fat. Immunohistochemical staining and molecular studies are often performed to identify specific markers and genetic abnormalities associated with the disease.

	== Differential Diagnosis ==		== Differential Diagnosis ==
	The differential diagnosis of subcutaneous T-cell lymphoma includes other types of [[cutaneous lymphoma]], [[panniculitis]], and [[infectious diseases]] that can mimic the clinical presentation of STCL. It is important to distinguish STCL from these conditions to ensure appropriate treatment.		The differential diagnosis of subcutaneous T-cell lymphoma includes other types of [[cutaneous lymphoma]], [[panniculitis]], and [[infectious diseases]] that can mimic the clinical presentation of STCL. It is important to distinguish STCL from these conditions to ensure appropriate treatment.

	== Treatment ==		== Treatment ==
	The treatment of subcutaneous T-cell lymphoma typically involves a combination of therapies, including [[chemotherapy]], [[radiation therapy]], and [[immunotherapy]]. The choice of treatment depends on the stage and extent of the disease, as well as the patient's overall health. In some cases, [[stem cell transplantation]] may be considered for patients with advanced or refractory disease.		The treatment of subcutaneous T-cell lymphoma typically involves a combination of therapies, including [[chemotherapy]], [[radiation therapy]], and [[immunotherapy]]. The choice of treatment depends on the stage and extent of the disease, as well as the patient's overall health. In some cases, [[stem cell transplantation]] may be considered for patients with advanced or refractory disease.

	== Prognosis ==		== Prognosis ==
	The prognosis of subcutaneous T-cell lymphoma varies depending on several factors, including the stage of the disease at diagnosis, the patient's response to treatment, and the presence of systemic symptoms. Early diagnosis and appropriate treatment are crucial for improving outcomes.		The prognosis of subcutaneous T-cell lymphoma varies depending on several factors, including the stage of the disease at diagnosis, the patient's response to treatment, and the presence of systemic symptoms. Early diagnosis and appropriate treatment are crucial for improving outcomes.

	== See Also ==		== See Also ==
	* [[Cutaneous T-cell lymphoma]]		* [[Cutaneous T-cell lymphoma]]
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	* [[Radiation therapy]]		* [[Radiation therapy]]
	* [[Immunotherapy]]		* [[Immunotherapy]]

	== References ==		== References ==
	{{Reflist}}		{{Reflist}}

	== External Links ==		== External Links ==
	{{Commons category\|Subcutaneous T-cell lymphoma}}		{{Commons category\|Subcutaneous T-cell lymphoma}}

	[[Category:Lymphoma]]		[[Category:Lymphoma]]
	[[Category:Cutaneous T-cell lymphoma]]		[[Category:Cutaneous T-cell lymphoma]]
	[[Category:Dermatology]]		[[Category:Dermatology]]
	[[Category:Oncology]]		[[Category:Oncology]]

	{{medicine-stub}}		{{medicine-stub}}

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[[file:PTCL-subtypes.jpg|thumb|left]] '''Subcutaneous T-cell lymphoma''' (STCL) is a rare type of [[cutaneous T-cell lymphoma]] (CTCL) that primarily affects the subcutaneous tissue, which is the layer of fat and connective tissue beneath the skin. This form of lymphoma is characterized by the presence of malignant T-cells in the subcutaneous tissue, leading to various clinical manifestations.

== Clinical Presentation ==
Patients with subcutaneous T-cell lymphoma typically present with [[nodules]], [[plaques]], or [[tumors]] in the subcutaneous tissue. These lesions can be painful and may be accompanied by systemic symptoms such as [[fever]], [[weight loss]], and [[fatigue]]. The skin overlying the affected areas may appear normal or show signs of [[erythema]] and [[ulceration]].

== Diagnosis ==
The diagnosis of subcutaneous T-cell lymphoma involves a combination of clinical evaluation, imaging studies, and histopathological examination. A [[biopsy]] of the affected tissue is essential for confirming the diagnosis. Histologically, STCL is characterized by the infiltration of atypical T-cells in the subcutaneous fat. Immunohistochemical staining and molecular studies are often performed to identify specific markers and genetic abnormalities associated with the disease.

== Differential Diagnosis ==
The differential diagnosis of subcutaneous T-cell lymphoma includes other types of [[cutaneous lymphoma]], [[panniculitis]], and [[infectious diseases]] that can mimic the clinical presentation of STCL. It is important to distinguish STCL from these conditions to ensure appropriate treatment.

== Treatment ==
The treatment of subcutaneous T-cell lymphoma typically involves a combination of therapies, including [[chemotherapy]], [[radiation therapy]], and [[immunotherapy]]. The choice of treatment depends on the stage and extent of the disease, as well as the patient's overall health. In some cases, [[stem cell transplantation]] may be considered for patients with advanced or refractory disease.

== Prognosis ==
The prognosis of subcutaneous T-cell lymphoma varies depending on several factors, including the stage of the disease at diagnosis, the patient's response to treatment, and the presence of systemic symptoms. Early diagnosis and appropriate treatment are crucial for improving outcomes.

== See Also ==
* [[Cutaneous T-cell lymphoma]]
* [[Lymphoma]]
* [[Chemotherapy]]
* [[Radiation therapy]]
* [[Immunotherapy]]

== References ==
{{Reflist}}

== External Links ==
{{Commons category|Subcutaneous T-cell lymphoma}}

[[Category:Lymphoma]]
[[Category:Cutaneous T-cell lymphoma]]
[[Category:Dermatology]]
[[Category:Oncology]]

{{medicine-stub}}

Subcutaneous T-cell lymphoma - Revision history

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