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Structural analog - Revision history
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<p><b>New page</b></p><div>'''Structural analog''' or '''structural analogue''' is a compound having a structure similar to that of another one, but differing from it in respect to a certain component. It can result from replacement of one atom with another atom or group of atoms. The concept of structural analogs is important in chemistry and biochemistry.<br />
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==Etymology==<br />
The term "analog" is derived from the Greek word "ανάλογος" (analogos), which means "proportional". In the context of biochemistry, an analog is a compound that resembles another in structure but not necessarily in function.<br />
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==Types of Structural Analogs==<br />
Structural analogs are classified into two types: <br />
* '''Complete analogs''': These are compounds that have the same atoms and the same bond connectivity, but different arrangement of atoms in space.<br />
* '''Partial analogs''': These are compounds that have the same atoms, but different bond connectivity.<br />
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==Applications==<br />
Structural analogs are widely used in medicinal chemistry to design new drugs. By modifying the structure of a known drug, it is possible to create a new compound with improved properties. This approach is known as [[Structure-activity relationship|structure-activity relationship]] (SAR) studies.<br />
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==Examples==<br />
Some examples of structural analogs include:<br />
* [[Methamphetamine]] and [[Amphetamine]]: Methamphetamine is a structural analog of amphetamine. The only difference between the two is the presence of a methyl group in methamphetamine.<br />
* [[Thalidomide]] and [[Pomalidomide]]: Pomalidomide is a structural analog of thalidomide. It has an additional amino group compared to thalidomide.<br />
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==See also==<br />
* [[Isomer]]<br />
* [[Homology (chemistry)]]<br />
* [[Bioisostere]]<br />
* [[Pharmacophore]]<br />
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==References==<br />
<references /><br />
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{{stub}}<br />
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[[Category:Chemistry]]<br />
[[Category:Biochemistry]]<br />
[[Category:Pharmacology]]</div>
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