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	<id>https://wikimd.com/index.php?action=history&amp;feed=atom&amp;title=Stromal_cell-derived_factor_1</id>
	<title>Stromal cell-derived factor 1 - Revision history</title>
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	<updated>2026-04-23T23:02:31Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
	<generator>MediaWiki 1.44.2</generator>
	<entry>
		<id>https://wikimd.com/index.php?title=Stromal_cell-derived_factor_1&amp;diff=6520123&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Stromal_cell-derived_factor_1&amp;diff=6520123&amp;oldid=prev"/>
		<updated>2025-03-18T00:54:30Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 00:54, 18 March 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l32&quot;&gt;Line 32:&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=Stromal_cell-derived_factor_1&amp;diff=6273453&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Stromal_cell-derived_factor_1&amp;diff=6273453&amp;oldid=prev"/>
		<updated>2025-02-11T03:50:06Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 03:50, 11 February 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l31&quot;&gt;Line 31:&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=Stromal_cell-derived_factor_1&amp;diff=5370280&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
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		<updated>2024-03-06T19:40:54Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;Stromal cell-derived factor 1&amp;#039;&amp;#039;&amp;#039; (SDF-1), also known as C-X-C motif chemokine 12 (CXCL12), is a [[chemokine]] protein that in humans is encoded by the CXCL12 gene. It plays a crucial role in [[hematopoiesis]] (the formation of blood cellular components) and [[angiogenesis]] (the formation of new blood vessels from pre-existing vessels).&lt;br /&gt;
&lt;br /&gt;
== Function ==&lt;br /&gt;
&lt;br /&gt;
SDF-1 is a member of the [[CXC chemokine]] family, a group of small cytokines or signaling proteins secreted by cells. Its primary function is to attract [[leukocytes]] towards sites of inflammation or injury. It does this by binding to the chemokine receptor CXCR4, a G protein-coupled receptor found on the surface of certain cells.&lt;br /&gt;
&lt;br /&gt;
In addition to its role in immune response, SDF-1 is also involved in the homing of hematopoietic stem cells to the bone marrow. It is a potent chemoattractant for [[hematopoietic stem cells]], and its interaction with CXCR4 is necessary for the migration of these cells into the bone marrow during embryogenesis.&lt;br /&gt;
&lt;br /&gt;
== Clinical Significance ==&lt;br /&gt;
&lt;br /&gt;
Given its role in hematopoiesis and angiogenesis, SDF-1 has been implicated in a number of clinical conditions. It is thought to play a role in the pathogenesis of certain cancers, including [[breast cancer]] and [[leukemia]], where it may promote tumor growth and metastasis. It has also been associated with cardiovascular diseases such as [[myocardial infarction]] and [[stroke]], where it may contribute to the repair and regeneration of damaged tissues.&lt;br /&gt;
&lt;br /&gt;
In addition, SDF-1 and its receptor CXCR4 have been identified as key players in the entry of [[HIV]] into cells. This has led to the development of drugs that target this interaction as a potential treatment for HIV infection.&lt;br /&gt;
&lt;br /&gt;
== See Also ==&lt;br /&gt;
&lt;br /&gt;
* [[Chemokine]]&lt;br /&gt;
* [[CXC chemokine]]&lt;br /&gt;
* [[CXCR4]]&lt;br /&gt;
* [[Hematopoiesis]]&lt;br /&gt;
* [[Angiogenesis]]&lt;br /&gt;
&lt;br /&gt;
== References ==&lt;br /&gt;
&lt;br /&gt;
{{reflist}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Chemokines]]&lt;br /&gt;
[[Category:Cytokines]]&lt;br /&gt;
[[Category:Immunology]]&lt;br /&gt;
[[Category:Hematology]]&lt;br /&gt;
[[Category:Angiogenesis]]&lt;br /&gt;
{{Chemokine-stub}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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