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	'''Stomatin''' is a [[protein]] that ~~in humans~~ is encoded by the [[STOM]] ~~gene~~. It is a member of the [[~~Stomatin~~ family]], which ~~includes proteins that~~ are involved in ~~various cellular processes~~. Stomatin is ~~primarily~~ found in ~~the~~ [[~~erythrocyte~~]] (red blood cell) membrane~~, but it is also present in other tissues~~.
			{{Infobox protein
			\| name = Stomatin
			\| image = <!-- Image of the protein, if available -->
			\| caption = <!-- Caption for the image -->
			\| symbol = STOM
			\| alt_symbols = <!-- Alternative symbols for the protein -->
			\| hgnc_id = 11378
			\| omim = 182900
			\| refseq = NM_001144
			\| uniprot = P27105
			\| chromosomal_location = 9q33.2
			}}

			'''Stomatin''' is a [[protein]] that is encoded by the [[STOM (gene)\|STOM gene]] in [[humans]]. It is a member of the [[stomatin family]] of proteins, which are involved in the regulation of ion channels and transporters. Stomatin is predominantly found in [[erythrocytes]] (red blood cells) and is associated with the [[cell membrane]].

	== Function ==		== Function ==
	Stomatin plays a crucial role in ~~maintaining~~ the ~~integrity~~ of ~~the~~ [[~~cell membrane~~]]. It is involved in the ~~regulation~~ of [[~~ion channels~~]]~~, which are responsible for the movement of ions across the cell membrane~~. ~~This regulation~~ is ~~essential for maintaining the balance of ions within the cell~~, ~~which is necessary for the cell's normal function.~~		Stomatin plays a crucial role in the regulation of [[ion channels]] and transporters, particularly in [[red blood cells]]. It is involved in the maintenance of [[cell membrane]] integrity and [[cellular homeostasis]]. Stomatin is known to interact with other proteins, such as [[band 3 protein]] and [[glucose transporter 1]], influencing their function and stability.

	~~Stomatin also plays a role in the function of the~~ [[~~sensory neurons~~]]~~. It is involved in the regulation of~~ [[~~mechanosensation~~]], ~~which is the process by which cells sense mechanical stimuli~~.

	== Clinical significance ==		== Clinical significance ==
	Mutations in the STOM gene can lead to [[hereditary stomatocytosis]], a ~~rare genetic disorder~~ characterized by ~~abnormal~~ red blood cells. ~~Symptoms of this disorder~~ can ~~include~~ [[anemia]], ~~[[jaundice]], and [[splenomegaly]] (enlarged spleen).~~		Mutations in the STOM gene can lead to various [[hematological disorders]], including [[hereditary stomatocytosis]], a condition characterized by the presence of stomatocytes in the blood. Stomatocytes are red blood cells with a mouth-shaped (stoma) area of central pallor. This condition can result in [[hemolytic anemia]], where red blood cells are destroyed faster than they can be produced.

	~~Stomatin has also been implicated in the development of certain types of [[cancer]]. Some studies have found that high levels of stomatin~~ are ~~associated with a poor prognosis in patients with [[colorectal cancer]] and [[breast cancer]]~~.

	== ~~Research~~ ==		== Interactions ==
	~~Research is ongoing~~ to ~~better understand the function of stomatin and its role in disease. This includes studies to investigate the role of stomatin in ion channel regulation and mechanosensation~~, ~~as well as research to explore the potential of targeting stomatin for the treatment of cancer.~~		Stomatin has been shown to interact with several other proteins, including:
			* [[Band 3 protein]]
			* [[Glucose transporter 1]]
			* [[Acetylcholinesterase]]

	~~[[File:Stomatin~~.~~png\|thumb\|right\|Stomatin protein structure. Image from Wikimedia Commons.]]~~		These interactions are important for the regulation of ion transport and the structural organization of the cell membrane.

	== See also ==		== See also ==
	* [[Stomatin family]]		* [[Stomatin family]]
	* [[Ion channel]]		* [[Ion channel]]
			* [[Red blood cell]]
	* [[Hereditary stomatocytosis]]		* [[Hereditary stomatocytosis]]
	* [[Mechanosensation]]

	== References ==		== References ==
	<references />		<references/>

	{{~~medicine~~-stub}}		{{Protein-stub}}

	[[Category:Proteins]]		[[Category:Proteins]]
	[[Category:~~Genes~~]]		[[Category:Human proteins]]
	[[Category:~~Cell biology~~]]		[[Category:Membrane proteins]]
	[[Category:~~Medical genetics]]~~		[[Category:Hematology]]
	~~[[Category:Oncology~~]]

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'''Stomatin''' is a [[protein]] that in humans is encoded by the [[STOM]] gene. It is a member of the [[Stomatin family]], which includes proteins that are involved in various cellular processes. Stomatin is primarily found in the [[erythrocyte]] (red blood cell) membrane, but it is also present in other tissues.

== Function ==
Stomatin plays a crucial role in maintaining the integrity of the [[cell membrane]]. It is involved in the regulation of [[ion channels]], which are responsible for the movement of ions across the cell membrane. This regulation is essential for maintaining the balance of ions within the cell, which is necessary for the cell's normal function.

Stomatin also plays a role in the function of the [[sensory neurons]]. It is involved in the regulation of [[mechanosensation]], which is the process by which cells sense mechanical stimuli.

== Clinical significance ==
Mutations in the STOM gene can lead to [[hereditary stomatocytosis]], a rare genetic disorder characterized by abnormal red blood cells. Symptoms of this disorder can include [[anemia]], [[jaundice]], and [[splenomegaly]] (enlarged spleen).

Stomatin has also been implicated in the development of certain types of [[cancer]]. Some studies have found that high levels of stomatin are associated with a poor prognosis in patients with [[colorectal cancer]] and [[breast cancer]].

== Research ==
Research is ongoing to better understand the function of stomatin and its role in disease. This includes studies to investigate the role of stomatin in ion channel regulation and mechanosensation, as well as research to explore the potential of targeting stomatin for the treatment of cancer.

[[File:Stomatin.png|thumb|right|Stomatin protein structure. Image from Wikimedia Commons.]]

== See also ==
* [[Stomatin family]]
* [[Ion channel]]
* [[Hereditary stomatocytosis]]
* [[Mechanosensation]]

== References ==
<references />

{{medicine-stub}}

[[Category:Proteins]]
[[Category:Genes]]
[[Category:Cell biology]]
[[Category:Medical genetics]]
[[Category:Oncology]]

Stomatin - Revision history

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