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<p><b>New page</b></p><div>[[File:PDB_1z2b_EBI.jpg|thumb|PDB_1z2b_EBI.jpg]] '''Stathmin''' is a highly conserved [[protein]] that plays a crucial role in the regulation of the [[microtubule]] dynamics within the [[cell]]. It is also known as [[oncoprotein 18]] (Op18), [[phosphoprotein]] p19, 19K, and metablastin. Stathmin is encoded by the ''STMN1'' gene in humans.<br />
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== Structure ==<br />
Stathmin is a small, cytoplasmic phosphoprotein composed of 149 amino acids. It contains several phosphorylation sites that are critical for its function. The protein has a coiled-coil structure that allows it to interact with [[tubulin]] and other microtubule-associated proteins.<br />
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== Function ==<br />
Stathmin regulates microtubule dynamics by promoting [[microtubule depolymerization]]. It binds to tubulin heterodimers, preventing their polymerization into microtubules. This activity is regulated by phosphorylation; when stathmin is phosphorylated, its ability to bind tubulin is inhibited, allowing microtubule polymerization to proceed.<br />
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== Role in Cell Cycle ==<br />
Stathmin is involved in the regulation of the [[cell cycle]], particularly during [[mitosis]]. It ensures proper spindle formation and function, which is essential for accurate chromosome segregation. Dysregulation of stathmin activity can lead to [[aneuploidy]] and has been implicated in [[cancer]] development.<br />
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== Clinical Significance ==<br />
Overexpression of stathmin has been observed in various types of [[cancer]], including [[breast cancer]], [[leukemia]], and [[lymphoma]]. Due to its role in cell division and its overexpression in tumors, stathmin is considered a potential target for cancer therapy. Inhibitors of stathmin function are being explored as therapeutic agents.<br />
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== Research ==<br />
Ongoing research is focused on understanding the precise mechanisms by which stathmin regulates microtubule dynamics and its role in cancer progression. Studies are also investigating the potential of stathmin as a biomarker for cancer diagnosis and prognosis.<br />
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== See also ==<br />
* [[Microtubule]]<br />
* [[Tubulin]]<br />
* [[Cell cycle]]<br />
* [[Mitosis]]<br />
* [[Cancer]]<br />
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== References ==<br />
{{Reflist}}<br />
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== External links ==<br />
{{Commons category|Stathmin}}<br />
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[[Category:Proteins]]<br />
[[Category:Cell biology]]<br />
[[Category:Oncology]]<br />
[[Category:Microtubules]]<br />
[[Category:Human proteins]]<br />
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