https://wikimd.org/index.php?action=history&feed=atom&title=SitagliptinSitagliptin - Revision history2026-04-25T22:29:20ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Sitagliptin&diff=6307257&oldid=prevPrab: CSV import2025-02-17T02:04:32Z<p>CSV import</p>
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</table>Prabhttps://wikimd.org/index.php?title=Sitagliptin&diff=125189&oldid=prevSpt: Marked this version for translation2019-07-13T13:19:36Z<p>Marked this version for translation</p>
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{{intro}}<br />
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor which is used in combination with [[diet]] and [[exercise]] in the therapy of [[type 2 diabetes]], either alone or in combination with other oral [[hypoglycemic agents]]. <br />
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Only rare isolated reports of liver injury due to sitagliptin have been published.<br />
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Sitagliptin (sit" a glip' tin) is an inhibitor of dipeptidyl peptidase-4, which is the major enzyme responsible for the degradation of glucagon-like peptide-1 (GLP-1), an important gastrointestinal hormone (incretin) that increases glucose dependent insulin secretion by the pancreas. By prolonging the effect of GLP-1, sitagliptin increases [[insulin]] levels and lowers blood glucose and helps in glycemic control in patients with [[type 2 diabetes]]. Sitagliptin <br />
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{{PAGENAME}} was approved for use in the United States in 2006 and was the first DPP-4 inhibitor introduced into clinical practice. The current indications are for management of glycemic control in [[type 2 diabetes]] used in combination with [[diet]] and [[exercise]], with or without other oral [[hypoglycemic agents]] or insulin. <br />
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Sitagliptin is available in tablets of 25, 50 and 100 mg under the brand name Januvia and in fixed combinations with metformin under the name Janumet. The typical dose of sitagliptin in adults is 100 mg once daily. <br />
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Adverse reactions to sitagliptin are not common, but may include [[headache]], [[nausea]], arthralgia and [[rash]]. [[Hypoglycemia]] is uncommon with sitagliptin alone (<1%), but occurs in higher rates when it is combined with other oral [[hypoglycemic agents]]. Sitagliptin has also been linked to rare instances of bullous pemphigoid and acute [[pancreatitis]] that can be severe and even fatal.<br />
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