https://wikimd.com/index.php?action=history&feed=atom&title=Sirtuin_7 Sirtuin 7 - Revision history 2026-04-09T02:07:07Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Sirtuin_7&diff=6529231&oldid=prev Prab at 17:38, 18 March 2025 2025-03-18T17:38:15Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:38, 18 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l24">Line 24:</td> <td colspan="2" class="diff-lineno">Line 24:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; 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font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">__NOINDEX__</del></div></td><td colspan="2" class="diff-side-added"></td></tr> </table> Prab https://wikimd.com/index.php?title=Sirtuin_7&diff=6508029&oldid=prev Prab: CSV import 2025-03-17T13:27:17Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:27, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l24">Line 24:</td> <td colspan="2" class="diff-lineno">Line 24:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; 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vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table> Prab https://wikimd.com/index.php?title=Sirtuin_7&diff=5433807&oldid=prev Prab: CSV import 2024-03-22T00:15:54Z <p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Sirtuin 7&#039;&#039;&#039; (&#039;&#039;&#039;SIRT7&#039;&#039;&#039;) is a member of the [[sirtuin]] family of proteins, which are a group of [[NAD+-dependent]] [[protein deacetylases]] involved in a wide array of cellular processes including [[metabolism]], [[DNA repair]], and [[aging]]. SIRT7 is primarily located in the [[nucleolus]], where it plays a crucial role in the maintenance of [[genomic stability]], [[ribosome biogenesis]], and [[transcriptional regulation]].<br /> <br /> == Function ==<br /> SIRT7 is known for its role in the deacetylation of [[histone]] H3K18Ac, a modification associated with actively transcribed genes. By deacetylating H3K18Ac, SIRT7 acts as a transcriptional repressor, maintaining the [[gene expression]] profiles necessary for the preservation of cellular identity and function. Additionally, SIRT7 has been implicated in the regulation of [[RNA polymerase I]]-mediated rRNA synthesis, a critical process for [[ribosome]] assembly and protein synthesis. Through these mechanisms, SIRT7 contributes to the regulation of cellular [[homeostasis]] and [[proliferation]].<br /> <br /> == Clinical Significance ==<br /> Alterations in SIRT7 expression and activity have been linked to various [[pathologies]], including [[cancer]], [[cardiovascular diseases]], and [[neurodegenerative diseases]]. In cancer, overexpression of SIRT7 has been observed in several types of tumors, where it is believed to promote tumorigenesis by enhancing ribosome biogenesis and protein synthesis, thereby supporting the increased metabolic demands of rapidly proliferating cells. Conversely, loss of SIRT7 function has been associated with premature aging phenotypes and reduced lifespan in model organisms, highlighting its potential role in the aging process.<br /> <br /> == Therapeutic Potential ==<br /> Given its involvement in critical cellular processes and disease, SIRT7 represents a promising target for therapeutic intervention. Modulation of SIRT7 activity could potentially offer new avenues for the treatment of SIRT7-related diseases. For instance, inhibitors of SIRT7 could be explored as anticancer agents, while activators of SIRT7 might have applications in combating aging and age-related diseases.<br /> <br /> == Research Directions ==<br /> Ongoing research aims to further elucidate the molecular mechanisms underlying SIRT7&#039;s functions and its interactions with other cellular components. Understanding the complex regulatory networks involving SIRT7 is essential for developing targeted therapies that can modulate its activity in a disease-specific manner.<br /> <br /> [[Category:Proteins]]<br /> [[Category:Enzymes]]<br /> [[Category:Genetics]]<br /> [[Category:Molecular biology]]<br /> [[Category:Biogerontology]]<br /> <br /> {{Template:Enzyme}}<br /> {{Template:Genetics-stub}}<br /> {{Template:Molecular-biology-stub}}<br /> {{medicine-stub}}</div> Prab