https://wikimd.org/index.php?action=history&feed=atom&title=Signal-regulatory_protein_alphaSignal-regulatory protein alpha - Revision history2026-05-02T23:38:48ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Signal-regulatory_protein_alpha&diff=5379005&oldid=prevPrab: CSV import2024-03-10T05:53:08Z<p>CSV import</p>
<p><b>New page</b></p><div>'''Signal-regulatory protein alpha''' ('''SIRPα'''), also known as '''CD172a''', is a protein that in humans is encoded by the '''SIRPA''' gene. SIRPα is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRPα is expressed predominantly by myeloid cells and is involved in a range of cellular processes such as [[neutrophil]] migration, [[phagocytosis]], and [[cell adhesion]].<br />
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==Structure==<br />
SIRPα is a transmembrane protein that consists of three immunoglobulin-like domains, a transmembrane region, and a cytoplasmic region that contains two immunoreceptor tyrosine-based inhibition motifs (ITIMs). The extracellular region of SIRPα interacts with [[CD47]], a widely expressed cell surface protein, to prevent phagocytosis.<br />
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==Function==<br />
SIRPα plays a crucial role in the regulation of many cellular processes. It is involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPα can also induce cell-cell adhesion when it interacts with CD47, which is present on the surface of many cell types. This interaction is important for the prevention of self-phagocytosis.<br />
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==Clinical significance==<br />
Alterations in the expression or function of SIRPα have been implicated in several diseases, including [[cancer]], [[autoimmune diseases]], and [[neurodegenerative diseases]]. In cancer, SIRPα-CD47 interaction can be exploited by cancer cells to evade immune surveillance. Therapies that block this interaction are currently being developed and tested in clinical trials.<br />
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==See also==<br />
* [[CD47]]<br />
* [[Phagocytosis]]<br />
* [[Immunoglobulin superfamily]]<br />
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==References==<br />
<references /><br />
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[[Category:Proteins]]<br />
[[Category:Immunology]]<br />
[[Category:Cell biology]]<br />
[[Category:Medicine]]<br />
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