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	~~'''Sevelamer''' is a [[~~phosphate ~~binding]] drug~~ used ~~to prevent [[hyperphosphatemia]]~~ in ~~patients with [[chronic kidney disease]]. When taken with meals, it binds to dietary phosphate and prevents its absorption. Sevelamer was approved by~~ the ~~U.S. [[Food and Drug Administration]] (FDA) on October 30, 1998.~~		{{Short description\|A phosphate binder used in the management of hyperphosphatemia}}

	~~==Mechanism~~ of ~~Action==~~		[[File:Sevelamer.png\|thumb\|right\|Chemical structure of Sevelamer]]
	Sevelamer operates by binding to dietary phosphate in the digestive tract and preventing its absorption into the body. This action helps to control [[serum phosphorus]] levels in patients with chronic kidney disease, particularly those on [[dialysis]].

	~~==Uses==~~		'''Sevelamer''' is a medication used to treat [[hyperphosphatemia]] (high blood phosphate levels) in patients with [[chronic kidney disease]] (CKD) who are on [[dialysis]]. It is a non-absorbed phosphate binder that works by binding phosphate in the [[gastrointestinal tract]], thereby preventing its absorption into the bloodstream.
	Sevelamer is ~~primarily~~ used to ~~control~~ hyperphosphatemia in patients with chronic kidney disease. It is ~~often prescribed to patients on dialysis~~, ~~as these individuals can have difficulty controlling their serum phosphorus levels~~.

	==~~Side Effects~~==		==Medical uses==
	~~Common side effects of sevelamer include [[nausea]]~~, [[~~vomiting~~]]~~, [[diarrhea]],~~ and [[~~abdominal pain~~]]. ~~Less common side effects can include [[itching]], [[rash]],~~ and ~~[[shortness of breath]]~~.		Sevelamer is primarily used to manage hyperphosphatemia in patients with CKD on dialysis. By controlling phosphate levels, it helps prevent complications such as [[bone disease]] and [[cardiovascular disease]] that are associated with high phosphate levels. Sevelamer is available in two forms: sevelamer hydrochloride and sevelamer carbonate. Both forms are effective in reducing serum phosphate levels.

	==~~Interactions~~==		==Mechanism of action==
	Sevelamer ~~can interact with other medications, including [[levothyroxine]] and [[ciprofloxacin]]~~. It is ~~important for patients~~ to ~~inform their healthcare provider~~ of ~~all medications they are currently taking~~.		Sevelamer acts by binding phosphate ions in the digestive tract. It is a polymeric compound that contains multiple amine groups, which become protonated in the acidic environment of the stomach. These protonated amine groups bind to negatively charged phosphate ions, forming an insoluble complex that is excreted in the feces. This reduces the absorption of phosphate from the diet, thereby lowering serum phosphate levels.

	==~~See Also~~==		==Side effects==
			Common side effects of sevelamer include [[gastrointestinal]] symptoms such as nausea, vomiting, diarrhea, and constipation. Some patients may experience abdominal pain or indigestion. Rarely, sevelamer can cause [[intestinal obstruction]] or [[perforation]]. Patients are advised to take sevelamer with meals to enhance its phosphate-binding effect.

			==Contraindications==
			Sevelamer is contraindicated in patients with [[bowel obstruction]] or known hypersensitivity to the drug. Caution is advised in patients with swallowing disorders or severe gastrointestinal motility disorders.

			==Pharmacokinetics==
			Sevelamer is not absorbed into the bloodstream and exerts its effects locally in the gastrointestinal tract. It is excreted unchanged in the feces. Because it is not systemically absorbed, it does not require dose adjustments based on renal or hepatic function.

			==Formulations==
			Sevelamer is available in tablet and powder form. The powder form can be mixed with water and taken orally. The choice of formulation may depend on patient preference and the ability to swallow tablets.

			==Related pages==
			* [[Chronic kidney disease]]
			* [[Dialysis]]
			* [[Hyperphosphatemia]]
	* [[Phosphate binder]]		* [[Phosphate binder]]
	* [[Hyperphosphatemia]]
	* [[Chronic kidney disease]]

	~~[[Category:Drugs]]~~
	[[Category:Phosphate binders]]		[[Category:Phosphate binders]]
	[[Category:~~Medications used in nephrology~~]]		[[Category:Renal drugs]]

	~~{{stub}}~~
	~~{{dictionary-stub1}}~~
	~~<gallery>~~
	~~File:Sevelamer.png\|Sevelamer~~
	~~</gallery>~~
	~~<gallery>~~
	~~File:Sevelamer.png\|Sevelamer~~
	~~</gallery>~~

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			File:Sevelamer.png\|Sevelamer
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	File:Sevelamer.png\|Sevelamer		File:Sevelamer.png\|Sevelamer
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			File:Sevelamer.png\|Sevelamer
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New page

'''Sevelamer''' is a [[phosphate binding]] drug used to prevent [[hyperphosphatemia]] in patients with [[chronic kidney disease]]. When taken with meals, it binds to dietary phosphate and prevents its absorption. Sevelamer was approved by the U.S. [[Food and Drug Administration]] (FDA) on October 30, 1998.

==Mechanism of Action==
Sevelamer operates by binding to dietary phosphate in the digestive tract and preventing its absorption into the body. This action helps to control [[serum phosphorus]] levels in patients with chronic kidney disease, particularly those on [[dialysis]].

==Uses==
Sevelamer is primarily used to control hyperphosphatemia in patients with chronic kidney disease. It is often prescribed to patients on dialysis, as these individuals can have difficulty controlling their serum phosphorus levels.

==Side Effects==
Common side effects of sevelamer include [[nausea]], [[vomiting]], [[diarrhea]], and [[abdominal pain]]. Less common side effects can include [[itching]], [[rash]], and [[shortness of breath]].

==Interactions==
Sevelamer can interact with other medications, including [[levothyroxine]] and [[ciprofloxacin]]. It is important for patients to inform their healthcare provider of all medications they are currently taking.

==See Also==
* [[Phosphate binder]]
* [[Hyperphosphatemia]]
* [[Chronic kidney disease]]

[[Category:Drugs]]
[[Category:Phosphate binders]]
[[Category:Medications used in nephrology]]

{{stub}}
{{dictionary-stub1}}

Sevelamer - Revision history

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