https://wikimd.org/index.php?action=history&feed=atom&title=Sensitization 2026-05-11T20:29:15Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Sensitization&diff=5294917&oldid=prev 2024-02-25T17:45:26Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Sensitization&#039;&#039;&#039; is a non-associative learning process in which repeated administration of a [[Stimulus (psychology)|stimulus]] results in the progressive amplification of a [[Reflex|reflex]] response. In the [[Neuroscience|neurosciences]], sensitization is a process that leads to the amplification of [[Neural plasticity|neural responses]] and has been implicated in various phenomena such as [[Drug addiction|addiction]], [[Chronic pain|chronic pain]], and [[Post-traumatic stress disorder|post-traumatic stress disorder]].<br /> <br /> == Overview ==<br /> Sensitization is thought to underlie both adaptive and maladaptive learning processes in the organism. In a benign form, it is a way for the organism to detect and respond to environmental stimuli that are potentially harmful. In a pathological form, it may lead to undesirable outcomes such as chronic pain and drug addiction.<br /> <br /> == Mechanisms ==<br /> The mechanisms of sensitization involve changes at the cellular level (cellular sensitization) and changes in the function of neural circuits (systems sensitization). Cellular sensitization involves changes in the function of neurons in response to excessive stimulation, such as the increased production of [[Neurotransmitter|neurotransmitters]] or the increased sensitivity of [[Receptor (biochemistry)|receptors]]. Systems sensitization involves changes in the function of neural circuits, such as the strengthening of synaptic connections between neurons.<br /> <br /> == Clinical implications ==<br /> Sensitization has been implicated in a number of clinical conditions, including chronic pain, drug addiction, and post-traumatic stress disorder. In chronic pain, sensitization may lead to an increased sensitivity to pain, known as [[Hyperalgesia|hyperalgesia]]. In drug addiction, sensitization may lead to an increased response to drugs, known as drug sensitization. In post-traumatic stress disorder, sensitization may lead to an increased response to stress, known as stress sensitization.<br /> <br /> == See also ==<br /> * [[Habituation]]<br /> * [[Long-term potentiation]]<br /> * [[Neural plasticity]]<br /> * [[Neurotransmitter]]<br /> * [[Receptor (biochemistry)]]<br /> <br /> [[Category:Neuroscience]]<br /> [[Category:Psychology]]<br /> [[Category:Learning]]<br /> <br /> {{stub}}</div>

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