Schaffer collateral - Revision history

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	[[Category:Neuroscience]]		[[Category:Neuroscience]]
	[[Category:Hippocampus]]		[[Category:Hippocampus]]
	~~<gallery>~~
	~~File:Schaffercollateral in the hippocampus.gif\|Schaffercollateral in the hippocampus~~
	~~File:Researcb Design.png\|Research Design~~
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			File:Schaffercollateral in the hippocampus.gif\|Schaffercollateral in the hippocampus
			File:Researcb Design.png\|Research Design
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	{{DISPLAYTITLE:Schaffer collateral}}		{{DISPLAYTITLE:Schaffer collateral}}

	~~== Schaffer collateral ==~~

	~~[[File:Schaffercollateral_in_the_hippocampus.gif\|thumb\|right\|Diagram of Schaffer collateral in the hippocampus]]~~

	The '''Schaffer collateral''' is a set of axon projections from the [[CA3 region]] of the [[hippocampus]] to the [[CA1 region]]. These projections are a crucial part of the [[trisynaptic circuit]] of the hippocampus, which is involved in the processing of [[memory]] and [[spatial navigation]]. The Schaffer collateral pathway is known for its role in [[synaptic plasticity]], particularly in the phenomenon of [[long-term potentiation]] (LTP), which is a cellular mechanism underlying learning and memory.		The '''Schaffer collateral''' is a set of axon projections from the [[CA3 region]] of the [[hippocampus]] to the [[CA1 region]]. These projections are a crucial part of the [[trisynaptic circuit]] of the hippocampus, which is involved in the processing of [[memory]] and [[spatial navigation]]. The Schaffer collateral pathway is known for its role in [[synaptic plasticity]], particularly in the phenomenon of [[long-term potentiation]] (LTP), which is a cellular mechanism underlying learning and memory.

	== Anatomy ==		== Anatomy ==

	The Schaffer collaterals originate from the [[pyramidal cells]] in the CA3 region of the hippocampus. These axons travel through the [[stratum radiatum]] of the CA1 region, where they form synapses with the dendrites of CA1 pyramidal neurons. The pathway is named after the German anatomist [[Karl Schaffer]], who first described these connections.		The Schaffer collaterals originate from the [[pyramidal cells]] in the CA3 region of the hippocampus. These axons travel through the [[stratum radiatum]] of the CA1 region, where they form synapses with the dendrites of CA1 pyramidal neurons. The pathway is named after the German anatomist [[Karl Schaffer]], who first described these connections.

	== Function ==		== Function ==

	The primary function of the Schaffer collateral pathway is to transmit information from the CA3 to the CA1 region of the hippocampus. This transmission is essential for the integration and processing of information within the hippocampal formation. The Schaffer collaterals are involved in the encoding and retrieval of [[episodic memory]] and play a significant role in the formation of [[spatial memory]].		The primary function of the Schaffer collateral pathway is to transmit information from the CA3 to the CA1 region of the hippocampus. This transmission is essential for the integration and processing of information within the hippocampal formation. The Schaffer collaterals are involved in the encoding and retrieval of [[episodic memory]] and play a significant role in the formation of [[spatial memory]].

	== Synaptic Plasticity ==		== Synaptic Plasticity ==

	~~[[File:Researcb_Design.png\|thumb\|left\|Research design in studies of synaptic plasticity]]~~

	The Schaffer collateral-CA1 synapse is a well-studied model for investigating synaptic plasticity. Long-term potentiation (LTP) at these synapses is a widely used experimental paradigm for studying the molecular and cellular mechanisms of learning and memory. LTP is characterized by a long-lasting increase in synaptic strength following high-frequency stimulation of the Schaffer collaterals. This process involves changes in [[neurotransmitter]] release, [[receptor]] sensitivity, and [[gene expression]].		The Schaffer collateral-CA1 synapse is a well-studied model for investigating synaptic plasticity. Long-term potentiation (LTP) at these synapses is a widely used experimental paradigm for studying the molecular and cellular mechanisms of learning and memory. LTP is characterized by a long-lasting increase in synaptic strength following high-frequency stimulation of the Schaffer collaterals. This process involves changes in [[neurotransmitter]] release, [[receptor]] sensitivity, and [[gene expression]].

	== Clinical Significance ==		== Clinical Significance ==

	Alterations in the function of the Schaffer collateral pathway have been implicated in various neurological disorders, including [[Alzheimer's disease]], [[epilepsy]], and [[schizophrenia]]. Understanding the mechanisms of synaptic plasticity at the Schaffer collateral-CA1 synapse is crucial for developing therapeutic strategies for these conditions.		Alterations in the function of the Schaffer collateral pathway have been implicated in various neurological disorders, including [[Alzheimer's disease]], [[epilepsy]], and [[schizophrenia]]. Understanding the mechanisms of synaptic plasticity at the Schaffer collateral-CA1 synapse is crucial for developing therapeutic strategies for these conditions.

	== Related pages ==		== Related pages ==

	* [[Hippocampus]]		* [[Hippocampus]]
	* [[Long-term potentiation]]		* [[Long-term potentiation]]

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	~~'''~~Schaffer Collateral''' is a type of [[axon]] that originates from the [[CA3]] region of the [[hippocampus]] and terminates in the [[CA1]] region. It is named after the neurologist [[Heinrich Schaffer]] who first described it. The Schaffer Collateral is an important part of the [[trisynaptic circuit]], which is the main circuitry of the hippocampus.		{{DISPLAYTITLE:Schaffer collateral}}

	== ~~Function~~ ==		== Schaffer collateral ==

			[[File:Schaffercollateral_in_the_hippocampus.gif\|thumb\|right\|Diagram of Schaffer collateral in the hippocampus]]

	The Schaffer ~~Collateral plays~~ a ~~crucial role in~~ the ~~functioning~~ of the ~~hippocampus. It is involved in the transmission of~~ [[~~electrical impulses~~]] ~~from the CA3 region~~ to the CA1 region. ~~This transmission~~ is ~~essential for~~ the processing of [[memory]] and [[~~learning~~]].		The '''Schaffer collateral''' is a set of axon projections from the [[CA3 region]] of the [[hippocampus]] to the [[CA1 region]]. These projections are a crucial part of the [[trisynaptic circuit]] of the hippocampus, which is involved in the processing of [[memory]] and [[spatial navigation]]. The Schaffer collateral pathway is known for its role in [[synaptic plasticity]], particularly in the phenomenon of [[long-term potentiation]] (LTP), which is a cellular mechanism underlying learning and memory.

	== ~~Structure~~ ==		== Anatomy ==

	The Schaffer ~~Collateral is a type of~~ [[~~excitatory synapse~~]]~~. It originates from the pyramidal cells~~ in the CA3 region ~~and terminates in~~ the ~~CA1 region~~. ~~The~~ axons of the ~~Schaffer Collateral~~ form synapses with the dendrites of ~~the~~ pyramidal ~~cells in~~ the ~~CA1 region~~.		The Schaffer collaterals originate from the [[pyramidal cells]] in the CA3 region of the hippocampus. These axons travel through the [[stratum radiatum]] of the CA1 region, where they form synapses with the dendrites of CA1 pyramidal neurons. The pathway is named after the German anatomist [[Karl Schaffer]], who first described these connections.

	== ~~Clinical Significance~~ ==		== Function ==

	~~Damage~~ to the ~~Schaffer Collateral can lead~~ to ~~impairments in memory~~ and ~~learning~~. ~~It has been implicated~~ in ~~various neurological disorders, including~~ [[~~Alzheimer's disease~~]] and [[~~epilepsy~~]].		The primary function of the Schaffer collateral pathway is to transmit information from the CA3 to the CA1 region of the hippocampus. This transmission is essential for the integration and processing of information within the hippocampal formation. The Schaffer collaterals are involved in the encoding and retrieval of [[episodic memory]] and play a significant role in the formation of [[spatial memory]].

	== ~~Research~~ ==		== Synaptic Plasticity ==

	Research ~~on the Schaffer Collateral has provided valuable insights into the functioning~~ of ~~the hippocampus and the mechanisms of memory and learning. It has also led to the development of new therapeutic strategies for neurological disorders.~~		[[File:Researcb_Design.png\|thumb\|left\|Research design in studies of synaptic plasticity]]

	~~== See Also ==~~		The Schaffer collateral-CA1 synapse is a well-studied model for investigating synaptic plasticity. Long-term potentiation (LTP) at these synapses is a widely used experimental paradigm for studying the molecular and cellular mechanisms of learning and memory. LTP is characterized by a long-lasting increase in synaptic strength following high-frequency stimulation of the Schaffer collaterals. This process involves changes in [[neurotransmitter]] release, [[receptor]] sensitivity, and [[gene expression]].

	* [[Hippocampus]]		== Clinical Significance ==
	* [[Axon]]
	* [[Synapse]]
	* [[Neuron]]
	* [[Neurology]]

	~~== References ==~~		Alterations in the function of the Schaffer collateral pathway have been implicated in various neurological disorders, including [[Alzheimer's disease]], [[epilepsy]], and [[schizophrenia]]. Understanding the mechanisms of synaptic plasticity at the Schaffer collateral-CA1 synapse is crucial for developing therapeutic strategies for these conditions.

	~~<references />~~		== Related pages ==

	~~{{stub}}~~		* [[Hippocampus]]
			* [[Long-term potentiation]]
			* [[Synaptic plasticity]]
			* [[Memory]]
			* [[Trisynaptic circuit]]

	~~[[Category:Neuroanatomy]]~~
	[[Category:Neuroscience]]		[[Category:Neuroscience]]
	[[Category:~~Memory~~]]		[[Category:Hippocampus]]
	~~[[Category:Learning]]~~
	~~== Schaffer collateral ==~~
	~~<gallery>~~
	~~File:Schaffercollateral in the hippocampus.gif\|Schaffer collateral in the hippocampus~~
	~~File:Researcb Design.png\|Research Design~~
	~~</gallery>~~

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	[[Category:Memory]]		[[Category:Memory]]
	[[Category:Learning]]		[[Category:Learning]]
			== Schaffer collateral ==
			<gallery>
			File:Schaffercollateral in the hippocampus.gif\|Schaffer collateral in the hippocampus
			File:Researcb Design.png\|Research Design
			</gallery>

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New page

'''Schaffer Collateral''' is a type of [[axon]] that originates from the [[CA3]] region of the [[hippocampus]] and terminates in the [[CA1]] region. It is named after the neurologist [[Heinrich Schaffer]] who first described it. The Schaffer Collateral is an important part of the [[trisynaptic circuit]], which is the main circuitry of the hippocampus.

== Function ==

The Schaffer Collateral plays a crucial role in the functioning of the hippocampus. It is involved in the transmission of [[electrical impulses]] from the CA3 region to the CA1 region. This transmission is essential for the processing of [[memory]] and [[learning]].

== Structure ==

The Schaffer Collateral is a type of [[excitatory synapse]]. It originates from the pyramidal cells in the CA3 region and terminates in the CA1 region. The axons of the Schaffer Collateral form synapses with the dendrites of the pyramidal cells in the CA1 region.

== Clinical Significance ==

Damage to the Schaffer Collateral can lead to impairments in memory and learning. It has been implicated in various neurological disorders, including [[Alzheimer's disease]] and [[epilepsy]].

== Research ==

Research on the Schaffer Collateral has provided valuable insights into the functioning of the hippocampus and the mechanisms of memory and learning. It has also led to the development of new therapeutic strategies for neurological disorders.

== See Also ==

* [[Hippocampus]]
* [[Axon]]
* [[Synapse]]
* [[Neuron]]
* [[Neurology]]

== References ==

<references />

{{stub}}

[[Category:Neuroanatomy]]
[[Category:Neuroscience]]
[[Category:Memory]]
[[Category:Learning]]