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<p><b>New page</b></p><div>[[File:Saridegib.svg|thumb|{{PAGENAME}}]]<br>'''Saridegib''' is a [[small molecule]] [[inhibitor]] that targets the [[Hedgehog signaling pathway]]. It was developed by [[Infinity Pharmaceuticals]] and was in [[clinical trials]] for the treatment of various types of [[cancer]], including [[basal cell carcinoma]] and [[pancreatic cancer]]. However, the development of Saridegib was discontinued in 2012 due to adverse side effects.<br />
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== Mechanism of Action ==<br />
Saridegib works by inhibiting the [[Hedgehog signaling pathway]], a pathway that is critical for cell growth and differentiation. In particular, it targets the [[Smoothened]] protein, a key component of the Hedgehog pathway. By inhibiting Smoothened, Saridegib prevents the activation of the Hedgehog pathway, thereby inhibiting the growth of cancer cells.<br />
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== Clinical Trials ==<br />
Saridegib was tested in several [[clinical trials]] for its efficacy in treating various types of cancer. In a Phase II trial for [[pancreatic cancer]], however, the drug was found to have severe side effects and did not improve survival rates. As a result, Infinity Pharmaceuticals decided to discontinue the development of Saridegib in 2012.<br />
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== Side Effects ==<br />
The side effects of Saridegib were found to be severe in clinical trials. These included [[muscle cramps]], [[hair loss]], [[weight loss]], [[taste disturbance]], and [[fatigue]]. Due to these adverse effects, the development of Saridegib was discontinued.<br />
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== Future Research ==<br />
Despite the discontinuation of Saridegib, research into the [[Hedgehog signaling pathway]] and its role in cancer continues. Other inhibitors of the pathway are currently being developed and tested, with the hope of finding a drug that can effectively target this pathway with fewer side effects.<br />
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{{Chemical compounds}}<br />
{{Cancer treatments}}<br />
{{Pharmacology-stub}}<br />
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[[Category:Chemical Compounds]]<br />
[[Category:Cancer Treatments]]<br />
[[Category:Pharmacology]]</div>Prab