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'''STAT3''' is a [[gene]] that encodes a [[transcription factor]] in the [[Signal transducer and activator of transcription]] (STAT) family. The protein encoded by this gene is a member of the STAT protein family. In response to [[cytokines]] and [[growth factors]], STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.

== Function ==
STAT3 is activated through [[phosphorylation]] in response to various cytokines and growth factors including [[IFNs]], [[EGF]], [[IL5]], [[IL6]], [[HGF]], [[LIF]] and [[BMP2]]. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase [[Rac1]] has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

== Clinical significance ==
Mutations in this gene are associated with [[hyper-IgM immunodeficiency syndrome]] and [[Job's syndrome]]. STAT3 has been shown to be involved in a variety of cancers, and is considered a potential therapeutic target.

== See also ==
* [[Signal transducer and activator of transcription]]
* [[Hyper-IgM syndrome]]
* [[Job's syndrome]]

== References ==
<references />

== External links ==
* [https://www.wikimd.com/wiki/STAT3 STAT3] at WikiMD

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[[Category:Genes]]
[[Category:Transcription factors]]
[[Category:Signal transduction]]
[[Category:Immunodeficiency]]
[[Category:Cancer]]

STAT3 - Revision history

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