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<p><b>New page</b></p><div>'''STAT2''' (Signal Transducer and Activator of Transcription 2) is a protein that in humans is encoded by the STAT2 gene. It is a member of the [[STAT protein family]] and plays a crucial role in cellular responses to [[interferon]] type I.<br />
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== Function ==<br />
STAT2 protein is a transcriptional activator that is vital for the cellular responses to [[interferon]] type I (IFN-alpha and IFN-beta). After the binding of type I interferons to receptors, the [[JAK kinase]] family is activated, leading to the phosphorylation of STAT1 and STAT2. The phosphorylated STATs then form a complex with [[IRF9]] to create the ISGF3 transcription factor, which binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes.<br />
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== Clinical significance ==<br />
Mutations in the STAT2 gene have been associated with susceptibility to [[mycobacterial]] and [[viral infections]]. In addition, STAT2 has been identified as a key player in the antiviral responses of cells, particularly in the context of [[Hepatitis C]] and [[Zika virus]] infections.<br />
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== Interactions ==<br />
STAT2 has been shown to [[Protein-protein interaction|interact]] with:<br />
* [[STAT1]]<br />
* [[IRF9]]<br />
* [[CREB-binding protein]]<br />
* [[Ep300]]<br />
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== References ==<br />
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== External links ==<br />
* [https://www.ncbi.nlm.nih.gov/gene/6773 STAT2] at the US National Library of Medicine [[Medical Subject Headings]] (MeSH)<br />
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[[Category:Transcription factors]]<br />
[[Category:Signal transduction]]<br />
[[Category:Human proteins]]<br />
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{{Transcription factors}}<br />
{{Signal transduction}}<br />
{{Human proteins}}<br />
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