https://wikimd.org/index.php?action=history&feed=atom&title=SIRPGSIRPG - Revision history2026-04-26T22:27:11ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=SIRPG&diff=5380972&oldid=prevPrab: CSV import2024-03-10T08:16:49Z<p>CSV import</p>
<p><b>New page</b></p><div>'''SIRPG''' (Signal Regulatory Protein Gamma) is a [[protein]] that in humans is encoded by the SIRPG [[gene]]. It is a member of the [[signal regulatory protein]] (SIRP) family, and also known as CD172g. SIRPG is involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.<br />
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== Function ==<br />
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The SIRPG protein is a receptor present on the surface of [[T cells]], [[natural killer cells]], and [[myeloid cells]]. It interacts with CD47 (a protein found on the surface of many cell types) to prevent the cells from being phagocytosed. This interaction is a critical part of the [[immune response]], as it helps to regulate the body's response to both self and foreign cells.<br />
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== Clinical significance ==<br />
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Alterations in the SIRPG gene have been associated with susceptibility to [[autoimmune diseases]], including [[rheumatoid arthritis]] and [[type 1 diabetes]]. In addition, SIRPG has been implicated in the progression of certain types of [[cancer]], including [[leukemia]] and [[lymphoma]].<br />
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== Research ==<br />
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Research into the role of SIRPG in the immune response and disease progression is ongoing. Current areas of focus include the potential for targeting the SIRPG-CD47 interaction in the treatment of cancer and autoimmune diseases.<br />
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== See also ==<br />
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* [[Signal regulatory protein]]<br />
* [[CD47]]<br />
* [[Immune response]]<br />
* [[Autoimmune diseases]]<br />
* [[Cancer]]<br />
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== References ==<br />
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<references /><br />
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[[Category:Proteins]]<br />
[[Category:Genes]]<br />
[[Category:Immunology]]<br />
[[Category:Medicine]]<br />
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