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<p><b>New page</b></p><div>'''SCG2''' or '''Secretogranin II''' is a protein that in humans is encoded by the SCG2 gene. It is a member of the [[granin]] family of neuroendocrine secretory proteins, which are precursors for various bioactive peptides. <br />
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== Function ==<br />
SCG2 is a [[chromogranin]] and [[secretogranin]] that are located in secretory vesicles of neurons and endocrine cells. This protein is a precursor for multiple [[peptide]]s including secretoneurin, which has been implicated in the regulation of [[neurotransmitter]] release and inflammatory processes. <br />
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== Clinical significance ==<br />
Alterations in the SCG2 gene have been associated with susceptibility to [[schizophrenia]]. Moreover, SCG2 has been identified as a potential biomarker for [[neuroendocrine tumors]].<br />
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== Structure ==<br />
The SCG2 gene is located on the short arm of [[chromosome 2]] (2q35-q36). It spans about 15 kb and consists of 7 exons. The SCG2 protein is a 617-amino acid polypeptide.<br />
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== See also ==<br />
* [[Chromogranin]]<br />
* [[Secretogranin]]<br />
* [[Neuroendocrine tumor]]<br />
* [[Schizophrenia]]<br />
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== References ==<br />
<references /><br />
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[[Category:Genes]]<br />
[[Category:Proteins]]<br />
[[Category:Neuroendocrine tumors]]<br />
[[Category:Schizophrenia]]<br />
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