https://wikimd.com/index.php?action=history&feed=atom&title=S1PR4
S1PR4 - Revision history
2026-04-21T10:38:21Z
Revision history for this page on the wiki
MediaWiki 1.44.2
https://wikimd.com/index.php?title=S1PR4&diff=6082876&oldid=prev
Prab: CSV import
2024-12-30T20:28:16Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 20:28, 30 December 2024</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''S1PR4''' <del style="font-weight: bold; text-decoration: none;">or '''</del>Sphingosine-1-phosphate receptor 4<del style="font-weight: bold; text-decoration: none;">''' </del>is a [[protein]] that <del style="font-weight: bold; text-decoration: none;">in humans is encoded by </del>the <del style="font-weight: bold; text-decoration: none;">S1PR4 </del>[[<del style="font-weight: bold; text-decoration: none;">gene</del>]]. <del style="font-weight: bold; text-decoration: none;">It </del>is <del style="font-weight: bold; text-decoration: none;">a member </del>of the [[sphingosine-1-phosphate receptor]] family, which <del style="font-weight: bold; text-decoration: none;">is </del>a <del style="font-weight: bold; text-decoration: none;">group </del>of [[<del style="font-weight: bold; text-decoration: none;">G protein-coupled receptor</del>]]<del style="font-weight: bold; text-decoration: none;">s that are cell surface receptors</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">= S1PR4 =</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''S1PR4''' <ins style="font-weight: bold; text-decoration: none;">(</ins>Sphingosine-1-phosphate receptor 4<ins style="font-weight: bold; text-decoration: none;">) </ins>is a [[<ins style="font-weight: bold; text-decoration: none;">G </ins>protein<ins style="font-weight: bold; text-decoration: none;">-coupled receptor</ins>]] that <ins style="font-weight: bold; text-decoration: none;">binds </ins>the <ins style="font-weight: bold; text-decoration: none;">lipid signaling molecule </ins>[[<ins style="font-weight: bold; text-decoration: none;">sphingosine-1-phosphate</ins>]] <ins style="font-weight: bold; text-decoration: none;">(S1P)</ins>. <ins style="font-weight: bold; text-decoration: none;">This receptor </ins>is <ins style="font-weight: bold; text-decoration: none;">part </ins>of the [[sphingosine-1-phosphate receptor]] family, which <ins style="font-weight: bold; text-decoration: none;">plays </ins>a <ins style="font-weight: bold; text-decoration: none;">crucial role in the regulation </ins>of <ins style="font-weight: bold; text-decoration: none;">various physiological processes, including </ins>[[<ins style="font-weight: bold; text-decoration: none;">immune system]] function and [[cardiovascular system|cardiovascular</ins>]] <ins style="font-weight: bold; text-decoration: none;">development</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Function ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Function ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>S1PR4 is <del style="font-weight: bold; text-decoration: none;">a receptor for the bioactive </del>[[<del style="font-weight: bold; text-decoration: none;">lipid</del>]] <del style="font-weight: bold; text-decoration: none;">sphingosine 1-phosphate (S1P). S1P </del>is <del style="font-weight: bold; text-decoration: none;">a circulating lipid that binds to the S1PR4 receptor, leading to </del>the <del style="font-weight: bold; text-decoration: none;">activation </del>of <del style="font-weight: bold; text-decoration: none;">intracellular signaling pathways</del>. <del style="font-weight: bold; text-decoration: none;">This receptor </del>is known to <del style="font-weight: bold; text-decoration: none;">regulate </del>the <del style="font-weight: bold; text-decoration: none;">immune system</del>, <del style="font-weight: bold; text-decoration: none;">particularly in the context of </del>[[<del style="font-weight: bold; text-decoration: none;">inflammation</del>]] and [[<del style="font-weight: bold; text-decoration: none;">autoimmune diseases</del>]].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>S1PR4 is <ins style="font-weight: bold; text-decoration: none;">primarily expressed in </ins>[[<ins style="font-weight: bold; text-decoration: none;">lymphoid tissue</ins>]] <ins style="font-weight: bold; text-decoration: none;">and </ins>is <ins style="font-weight: bold; text-decoration: none;">involved in </ins>the <ins style="font-weight: bold; text-decoration: none;">modulation </ins>of <ins style="font-weight: bold; text-decoration: none;">[[immune cell]] trafficking and function</ins>. <ins style="font-weight: bold; text-decoration: none;">It </ins>is known to <ins style="font-weight: bold; text-decoration: none;">influence </ins>the <ins style="font-weight: bold; text-decoration: none;">behavior of [[T cells]]</ins>, [[<ins style="font-weight: bold; text-decoration: none;">B cells</ins>]]<ins style="font-weight: bold; text-decoration: none;">, </ins>and [[<ins style="font-weight: bold; text-decoration: none;">natural killer cells</ins>]]<ins style="font-weight: bold; text-decoration: none;">. The receptor's activity is mediated by its interaction with intracellular [[G proteins]], which transduce signals to downstream effectors, influencing cell migration, proliferation, and survival</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== Clinical <del style="font-weight: bold; text-decoration: none;">significance </del>==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Clinical <ins style="font-weight: bold; text-decoration: none;">Significance </ins>==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Alterations in <del style="font-weight: bold; text-decoration: none;">the function of </del>S1PR4 have been implicated in <del style="font-weight: bold; text-decoration: none;">a variety of diseases, including </del>[[<del style="font-weight: bold; text-decoration: none;">cancer</del>]], [[autoimmune <del style="font-weight: bold; text-decoration: none;">diseases</del>]]<del style="font-weight: bold; text-decoration: none;">, </del>and [[<del style="font-weight: bold; text-decoration: none;">inflammatory diseases]]. For example, in certain types of </del>cancer<del style="font-weight: bold; text-decoration: none;">, the overexpression of S1PR4 has been associated with increased [[tumor]] growth and [[metastasis</del>]]. <del style="font-weight: bold; text-decoration: none;">In autoimmune diseases, S1PR4 has been found to play </del>a <del style="font-weight: bold; text-decoration: none;">role </del>in <del style="font-weight: bold; text-decoration: none;">the migration and function of </del>immune <del style="font-weight: bold; text-decoration: none;">cells</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Alterations in S1PR4 <ins style="font-weight: bold; text-decoration: none;">signaling </ins>have been implicated in <ins style="font-weight: bold; text-decoration: none;">various </ins>[[<ins style="font-weight: bold; text-decoration: none;">disease</ins>]] <ins style="font-weight: bold; text-decoration: none;">states</ins>, <ins style="font-weight: bold; text-decoration: none;">including </ins>[[autoimmune <ins style="font-weight: bold; text-decoration: none;">disorders</ins>]] and [[cancer]]. <ins style="font-weight: bold; text-decoration: none;">The receptor is </ins>a <ins style="font-weight: bold; text-decoration: none;">potential target for therapeutic intervention </ins>in <ins style="font-weight: bold; text-decoration: none;">conditions where </ins>immune <ins style="font-weight: bold; text-decoration: none;">cell regulation is disrupted</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Research ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Research ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Research into </del>the role of S1PR4 in <del style="font-weight: bold; text-decoration: none;">disease is ongoing, with a particular focus on </del>its potential as a <del style="font-weight: bold; text-decoration: none;">therapeutic target</del>. <del style="font-weight: bold; text-decoration: none;">For example, drugs that target </del>S1PR4 <del style="font-weight: bold; text-decoration: none;">are being developed for the treatment </del>of <del style="font-weight: bold; text-decoration: none;">autoimmune diseases and cancer</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Recent studies have focused on </ins>the role of S1PR4 in <ins style="font-weight: bold; text-decoration: none;">[[inflammatory diseases]] and </ins>its potential as a <ins style="font-weight: bold; text-decoration: none;">biomarker for disease progression</ins>. <ins style="font-weight: bold; text-decoration: none;">The development of selective </ins>S1PR4 <ins style="font-weight: bold; text-decoration: none;">agonists and antagonists is an area </ins>of <ins style="font-weight: bold; text-decoration: none;">active research, aiming to modulate immune responses in a controlled manner</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[File:S1PR4.png|thumb|right|S1PR4 protein structure]]</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== See <ins style="font-weight: bold; text-decoration: none;">Also </ins>==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== See <del style="font-weight: bold; text-decoration: none;">also </del>==</div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [[Sphingosine-1-phosphate receptor]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [[Sphingosine-1-phosphate receptor]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [[G protein-coupled receptor]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [[G protein-coupled receptor]]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* [[<del style="font-weight: bold; text-decoration: none;">Lipid signaling</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* [[<ins style="font-weight: bold; text-decoration: none;">Immune system</ins>]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== References ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== References ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><references /></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><references/></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== External Links ==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* [https://www.wikimd.com/wiki/S1PR4 S1PR4 on WikiMD]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>{{<del style="font-weight: bold; text-decoration: none;">G protein</del>-<del style="font-weight: bold; text-decoration: none;">coupled receptors</del>}}</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>{{<ins style="font-weight: bold; text-decoration: none;">Receptor</ins>-<ins style="font-weight: bold; text-decoration: none;">stub</ins>}}</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>{{<del style="font-weight: bold; text-decoration: none;">Transmembrane receptor: G protein-coupled receptors}}</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>{{<ins style="font-weight: bold; text-decoration: none;">GPCR</ins>}}</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">{{medicine-stub</del>}}</div></td><td colspan="2" class="diff-side-added"></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Receptors]]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Immune system]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:G protein-coupled receptors]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:G protein-coupled receptors]]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Category:Human proteins]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Category:Genes]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Category:Medicine]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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https://wikimd.com/index.php?title=S1PR4&diff=5379024&oldid=prev
Prab: CSV import
2024-03-10T05:54:49Z
<p>CSV import</p>
<p><b>New page</b></p><div>'''S1PR4''' or '''Sphingosine-1-phosphate receptor 4''' is a [[protein]] that in humans is encoded by the S1PR4 [[gene]]. It is a member of the [[sphingosine-1-phosphate receptor]] family, which is a group of [[G protein-coupled receptor]]s that are cell surface receptors.<br />
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== Function ==<br />
S1PR4 is a receptor for the bioactive [[lipid]] sphingosine 1-phosphate (S1P). S1P is a circulating lipid that binds to the S1PR4 receptor, leading to the activation of intracellular signaling pathways. This receptor is known to regulate the immune system, particularly in the context of [[inflammation]] and [[autoimmune diseases]].<br />
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== Clinical significance ==<br />
Alterations in the function of S1PR4 have been implicated in a variety of diseases, including [[cancer]], [[autoimmune diseases]], and [[inflammatory diseases]]. For example, in certain types of cancer, the overexpression of S1PR4 has been associated with increased [[tumor]] growth and [[metastasis]]. In autoimmune diseases, S1PR4 has been found to play a role in the migration and function of immune cells.<br />
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== Research ==<br />
Research into the role of S1PR4 in disease is ongoing, with a particular focus on its potential as a therapeutic target. For example, drugs that target S1PR4 are being developed for the treatment of autoimmune diseases and cancer.<br />
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[[File:S1PR4.png|thumb|right|S1PR4 protein structure]]<br />
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== See also ==<br />
* [[Sphingosine-1-phosphate receptor]]<br />
* [[G protein-coupled receptor]]<br />
* [[Lipid signaling]]<br />
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== References ==<br />
<references /><br />
<br />
{{G protein-coupled receptors}}<br />
{{Transmembrane receptor: G protein-coupled receptors}}<br />
{{medicine-stub}}<br />
<br />
[[Category:G protein-coupled receptors]]<br />
[[Category:Human proteins]]<br />
[[Category:Genes]]<br />
[[Category:Medicine]]</div>
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