https://wikimd.com/index.php?action=history&feed=atom&title=S1PR1S1PR1 - Revision history2026-04-23T22:03:56ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.com/index.php?title=S1PR1&diff=5380074&oldid=prevPrab: CSV import2024-03-10T07:10:23Z<p>CSV import</p>
<p><b>New page</b></p><div>'''S1PR1''' or '''Sphingosine-1-phosphate receptor 1''' is a [[G protein-coupled receptor]] that is encoded by the S1PR1 gene in humans. It is also known as endothelial differentiation gene-1 (EDG1). S1PR1 is a member of the [[sphingosine-1-phosphate receptor]] family and has been shown to mediate cellular responses to [[sphingosine 1-phosphate]] (S1P), a bioactive [[lipid]] mediator.<br />
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== Function ==<br />
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S1PR1 is involved in several physiological and pathological processes. It plays a crucial role in the regulation of [[lymphocyte]] trafficking, [[vascular development]] and integrity, and [[inflammation]]. S1PR1 signaling also contributes to the pathogenesis of various diseases, including [[cancer]], [[autoimmune diseases]], and [[inflammatory diseases]].<br />
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== Structure ==<br />
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S1PR1 is a seven-transmembrane domain receptor that is coupled to the [[G protein]] Gi. Upon binding to its ligand, S1P, it undergoes conformational changes that allow it to activate the G protein, leading to the activation of downstream signaling pathways.<br />
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== Clinical significance ==<br />
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Alterations in S1PR1 function and expression have been associated with various diseases. For instance, overexpression of S1PR1 has been observed in several types of cancer, including [[breast cancer]] and [[lung cancer]], and is associated with poor prognosis. In autoimmune diseases, such as [[multiple sclerosis]], S1PR1 is a target of the drug [[fingolimod]], which acts by modulating S1PR1 signaling.<br />
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== See also ==<br />
* [[Sphingosine-1-phosphate receptor]]<br />
* [[G protein-coupled receptor]]<br />
* [[Fingolimod]]<br />
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== References ==<br />
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[[Category:G protein-coupled receptors]]<br />
[[Category:Human proteins]]<br />
[[Category:Signal transduction]]<br />
{{G protein-coupled receptors}}<br />
{{Human chromosome 1 gene stubs}}<br />
{{medicine-stub}}</div>Prab