https://wikimd.org/index.php?action=history&feed=atom&title=Roxindole 2026-04-25T01:47:21Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Roxindole&diff=6333484&oldid=prev 2025-02-20T01:19:10Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:19, 20 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l30">Line 30:</td> <td colspan="2" class="diff-lineno">Line 30:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;gallery&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Roxindole.png|Roxindole</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/gallery&gt;</ins></div></td></tr> </table>

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<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Roxindole&#039;&#039;&#039; is a [[dopamine]] [[agonist]] that was originally developed in the 1980s. It is a derivative of [[indole]], and has been studied for its potential use in the treatment of [[Parkinson&#039;s disease]] and [[schizophrenia]]. <br /> <br /> == History ==<br /> <br /> Roxindole was first synthesized in the 1980s by the pharmaceutical company [[Sandoz]]. It was initially developed as a potential treatment for Parkinson&#039;s disease, due to its ability to stimulate dopamine receptors in the brain. <br /> <br /> == Pharmacology ==<br /> <br /> Roxindole acts as a dopamine agonist, meaning it stimulates the activity of dopamine receptors in the brain. It has a high affinity for the D2 and D3 dopamine receptors, and a lower affinity for the D1 receptor. <br /> <br /> In addition to its dopamine agonist activity, roxindole also has some affinity for the [[serotonin]] 5-HT1A and 5-HT2A receptors, and the [[adrenergic]] alpha-1 and alpha-2 receptors. <br /> <br /> == Clinical Use ==<br /> <br /> While roxindole was initially developed for the treatment of Parkinson&#039;s disease, it has also been studied for its potential use in the treatment of schizophrenia. However, as of 2021, it is not currently approved for use in any country. <br /> <br /> == Side Effects ==<br /> <br /> As with any medication, roxindole has the potential to cause side effects. These can include [[nausea]], [[vomiting]], [[dizziness]], and [[insomnia]]. In rare cases, it can also cause more serious side effects such as [[hallucinations]] and [[psychosis]]. <br /> <br /> == See Also ==<br /> <br /> * [[Dopamine agonist]]<br /> * [[Parkinson&#039;s disease]]<br /> * [[Schizophrenia]]<br /> <br /> [[Category:Drugs]]<br /> [[Category:Dopamine agonists]]<br /> [[Category:Indoles]]<br /> <br /> {{stub}}</div>

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