https://wikimd.org/index.php?action=history&feed=atom&title=Rosolutamide 2026-04-27T06:59:38Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Rosolutamide&diff=6428127&oldid=prev 2025-03-05T06:22:59Z

<p>CSV import</p> <p><b>New page</b></p><div>{{Short description|Nonsteroidal antiandrogen}}<br /> {{Drugbox<br /> | verifiedfields = changed<br /> | verifiedrevid = 477002295<br /> | image = Rosolutamide.svg<br /> | image_size = 200px<br /> | image_alt = Chemical structure of Rosolutamide<br /> | image_caption = Chemical structure of Rosolutamide<br /> }}<br /> <br /> &#039;&#039;&#039;Rosolutamide&#039;&#039;&#039; is a [[nonsteroidal antiandrogen]] (NSAA) that was developed for the treatment of [[prostate cancer]]. It belongs to a class of drugs that work by blocking the effects of [[androgens]], such as [[testosterone]], in the body. This action is beneficial in conditions like prostate cancer, where androgens can promote the growth of cancer cells.<br /> <br /> ==Mechanism of Action==<br /> Rosolutamide functions by competitively inhibiting the [[androgen receptor]] (AR), which is a type of [[nuclear receptor]] that is activated by binding any of the androgenic hormones, such as testosterone or dihydrotestosterone (DHT). By blocking these hormones from binding to the AR, Rosolutamide prevents the activation of androgen-responsive genes, thereby inhibiting the growth of androgen-dependent cancer cells.<br /> <br /> ==Pharmacokinetics==<br /> The pharmacokinetic profile of Rosolutamide includes its absorption, distribution, metabolism, and excretion. As a nonsteroidal compound, it is absorbed orally and undergoes hepatic metabolism. The metabolites are then excreted primarily through the urine. The half-life of Rosolutamide allows for once-daily dosing, which can improve patient compliance.<br /> <br /> ==Clinical Use==<br /> Rosolutamide is primarily used in the treatment of [[prostate cancer]], particularly in cases where the cancer is resistant to other forms of hormone therapy. It is often used in combination with other treatments, such as [[gonadotropin-releasing hormone]] (GnRH) analogs, to achieve maximal androgen blockade.<br /> <br /> ==Side Effects==<br /> Common side effects of Rosolutamide include [[gynecomastia]], [[hot flashes]], and [[gastrointestinal disturbances]]. As with other antiandrogens, there is a risk of liver toxicity, and liver function should be monitored during treatment. Patients may also experience fatigue and decreased libido.<br /> <br /> ==Development and History==<br /> Rosolutamide was developed as part of a series of nonsteroidal antiandrogens aimed at providing effective treatment options for prostate cancer with fewer side effects compared to steroidal antiandrogens. Its development was part of a broader effort to improve the quality of life for patients undergoing hormone therapy for prostate cancer.<br /> <br /> ==Related Pages==<br /> * [[Prostate cancer]]<br /> * [[Androgen receptor]]<br /> * [[Nonsteroidal antiandrogen]]<br /> * [[Hormone therapy (oncology)]]<br /> <br /> [[Category:Nonsteroidal antiandrogens]]<br /> [[Category:Prostate cancer treatments]]</div>

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