https://wikimd.com/index.php?action=history&feed=atom&title=Robert_LefkowitzRobert Lefkowitz - Revision history2026-04-21T21:12:29ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.com/index.php?title=Robert_Lefkowitz&diff=5811339&oldid=prevPrab: CSV import2024-05-22T21:55:47Z<p>CSV import</p>
<p><b>New page</b></p><div>[[File:Robert_Lefkowitz_2_2012.jpg|thumb|Robert Lefkowitz 2 2012]] '''Robert Lefkowitz'''<br />
<br />
'''Robert Joseph Lefkowitz''' (born April 15, 1943) is an American [[physician]] and [[biochemist]] who is best known for his groundbreaking work on [[G protein-coupled receptors]] (GPCRs). He was awarded the [[Nobel Prize in Chemistry]] in 2012, along with [[Brian Kobilka]], for their discoveries that have significantly advanced the understanding of how these receptors function.<br />
<br />
== Early Life and Education ==<br />
Lefkowitz was born in [[New York City]], [[New York]]. He attended the [[Bronx High School of Science]] and later earned his [[Bachelor of Arts|B.A.]] in [[chemistry]] from [[Columbia University]] in 1962. He continued his education at [[Columbia University College of Physicians and Surgeons]], where he received his [[Doctor of Medicine|M.D.]] in 1966.<br />
<br />
== Career ==<br />
After completing his medical degree, Lefkowitz served as a clinical and research associate at the [[National Institutes of Health]] (NIH) from 1968 to 1970. He then completed his medical residency and fellowship in [[cardiology]] at the [[Massachusetts General Hospital]].<br />
<br />
In 1973, Lefkowitz joined the faculty at [[Duke University]], where he has spent the majority of his career. He is currently a James B. Duke Professor of Medicine and a Professor of Biochemistry and Chemistry at Duke University Medical Center.<br />
<br />
== Research ==<br />
Lefkowitz's research has primarily focused on the molecular properties and regulatory mechanisms of GPCRs. These receptors play a crucial role in cellular communication and are the target of a large number of pharmaceutical drugs. His work has led to a deeper understanding of how these receptors function and how they can be targeted for therapeutic purposes.<br />
<br />
One of his most significant contributions was the discovery of the [[beta-adrenergic receptor]], a type of GPCR that responds to [[epinephrine]] and [[norepinephrine]]. This discovery has had profound implications for the treatment of various cardiovascular diseases.<br />
<br />
== Awards and Honors ==<br />
Lefkowitz has received numerous awards and honors throughout his career, including:<br />
* The [[Nobel Prize in Chemistry]] (2012)<br />
* The [[National Medal of Science]] (2007)<br />
* The [[Shaw Prize]] in Life Science and Medicine (2007)<br />
* The [[Albany Medical Center Prize]] (2012)<br />
<br />
== Personal Life ==<br />
Lefkowitz is married and has five children. He is also known for his mentorship and has trained many prominent scientists in the field of biochemistry and pharmacology.<br />
<br />
== See Also ==<br />
* [[G protein-coupled receptor]]<br />
* [[Brian Kobilka]]<br />
* [[Nobel Prize in Chemistry]]<br />
* [[National Institutes of Health]]<br />
* [[Duke University]]<br />
<br />
== References ==<br />
{{Reflist}}<br />
<br />
== External Links ==<br />
{{Commons category|Robert Lefkowitz}}<br />
<br />
{{Nobel Prize in Chemistry Laureates 2011-2020}}<br />
{{Authority control}}<br />
<br />
[[Category:1943 births]]<br />
[[Category:Living people]]<br />
[[Category:American biochemists]]<br />
[[Category:American Nobel laureates]]<br />
[[Category:Nobel laureates in Chemistry]]<br />
[[Category:Columbia University alumni]]<br />
[[Category:Duke University faculty]]<br />
[[Category:Members of the United States National Academy of Sciences]]<br />
[[Category:National Medal of Science laureates]]<br />
[[Category:People from New York City]]<br />
[[Category:Physicians from New York City]]<br />
[[Category:American cardiologists]]<br />
[[Category:Bronx High School of Science alumni]]<br />
<br />
{{medicine-stub}}</div>Prab