https://wikimd.org/index.php?action=history&feed=atom&title=Ro_04-6790Ro 04-6790 - Revision history2026-04-28T01:34:08ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Ro_04-6790&diff=6343542&oldid=prevPrab: CSV import2025-02-24T23:54:36Z<p>CSV import</p>
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<p><b>New page</b></p><div>'''Ro 04-6790''' is a [[pharmacological]] compound that acts as a [[5-HT6 receptor]] antagonist. It was developed by [[Hoffmann-La Roche]], a Swiss multinational healthcare company. Ro 04-6790 is primarily used in scientific research to investigate the role of 5-HT6 receptors in the brain.<br />
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== History ==<br />
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Ro 04-6790 was first synthesized by researchers at Hoffmann-La Roche in the late 20th century. The compound was developed as part of a broader effort to understand the role of various [[serotonin receptor]] subtypes in the brain and their potential as targets for therapeutic intervention.<br />
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== Pharmacology ==<br />
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Ro 04-6790 is a potent and selective antagonist of the 5-HT6 receptor, a subtype of serotonin receptor. This receptor is primarily found in the [[central nervous system]], particularly in regions of the brain associated with learning and memory. By blocking the action of serotonin at these receptors, Ro 04-6790 can modulate neuronal activity in these regions.<br />
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== Research Applications ==<br />
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Ro 04-6790 has been used in a variety of preclinical studies to investigate the role of 5-HT6 receptors in the brain. These studies have suggested that 5-HT6 receptor antagonists like Ro 04-6790 may have potential therapeutic applications in conditions such as [[schizophrenia]], [[Alzheimer's disease]], and [[obesity]].<br />
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== Safety and Toxicity ==<br />
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As a research compound, Ro 04-6790 is not approved for use in humans. Therefore, information on its safety and toxicity is limited to preclinical studies. In these studies, Ro 04-6790 has generally been well-tolerated, with no significant adverse effects reported at doses that produce a pharmacological effect.<br />
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== See Also ==<br />
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* [[5-HT6 receptor]]<br />
* [[Serotonin receptor]]<br />
* [[Hoffmann-La Roche]]<br />
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== References ==<br />
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<references /><br />
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[[Category:Pharmacology]]<br />
[[Category:Research compounds]]<br />
[[Category:Serotonin receptor antagonists]]<br />
{{Pharma-stub}}</div>Prab