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'''Rhodopsin kinase''' (also known as '''GRK1''') is an [[enzyme]] that in humans is encoded by the GRK1 [[gene]]. It is a member of the G protein-coupled receptor kinase (GRK) family and plays a key role in the [[visual phototransduction]] pathway.

== Function ==

Rhodopsin kinase is a key player in the [[Visual system|visual phototransduction cascade]], which is a process that converts light into electrical signals in the [[Photoreceptor cell|photoreceptor cells]] of the retina. The kinase is responsible for the phosphorylation of the light-activated form of rhodopsin (metarhodopsin II), which initiates the deactivation and recovery processes of the phototransduction cascade.

== Structure ==

The structure of rhodopsin kinase is similar to that of other [[Protein kinase|protein kinases]]. It has a catalytic domain and a regulatory domain. The catalytic domain is responsible for the phosphorylation of rhodopsin, while the regulatory domain is involved in the recognition and binding of the substrate.

== Clinical significance ==

Mutations in the GRK1 gene can lead to various forms of [[Night blindness|night blindness]]. For example, Oguchi disease, a rare form of stationary night blindness, is caused by mutations in either the GRK1 gene or the arrestin gene.

== See also ==

* [[G protein-coupled receptor kinase]]
* [[Rhodopsin]]
* [[Phototransduction]]

== References ==

{{Reflist}}

[[Category:EC 2.7.11]]
[[Category:Human proteins]]
[[Category:Vision]]
[[Category:Signal transduction]]
{{enzyme-stub}}

Rhodopsin kinase - Revision history

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