https://wikimd.org/index.php?action=history&feed=atom&title=Reviparin_sodiumReviparin sodium - Revision history2026-04-26T23:48:20ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Reviparin_sodium&diff=6341068&oldid=prevPrab: CSV import2025-02-23T21:05:43Z<p>CSV import</p>
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</table>Prabhttps://wikimd.org/index.php?title=Reviparin_sodium&diff=5344406&oldid=prevPrab: CSV import2024-03-02T16:05:15Z<p>CSV import</p>
<p><b>New page</b></p><div>'''Reviparin sodium''' is a [[low molecular weight heparin]] (LMWH) that is primarily used as an [[anticoagulant]] for the prevention and treatment of [[deep vein thrombosis]] (DVT) and [[pulmonary embolism]] (PE). It is a derivative of [[heparin]], a naturally occurring anticoagulant produced by basophils and mast cells.<br />
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==Pharmacology==<br />
Reviparin sodium works by enhancing the inhibition of [[Factor Xa]] and [[thrombin]] by increasing antithrombin III activity. This prevents the conversion of fibrinogen to [[fibrin]], thereby inhibiting blood clot formation. It has a higher ratio of anti-Factor Xa to anti-thrombin activity compared to unfractionated heparin, which may contribute to its superior efficacy and safety profile.<br />
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==Clinical Use==<br />
Reviparin sodium is indicated for the prevention of DVT and PE in patients undergoing orthopedic or abdominal surgery, and in acutely ill medical patients at risk for thromboembolic complications. It is also used for the treatment of acute DVT and PE, and for the prevention of clotting in the extracorporeal circulation during [[hemodialysis]].<br />
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==Side Effects==<br />
The most common side effect of reviparin sodium is bleeding. Other side effects may include [[thrombocytopenia]], hypersensitivity reactions, and, rarely, [[osteoporosis]] with long-term use. <br />
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==Contraindications==<br />
Reviparin sodium is contraindicated in patients with active major bleeding, severe thrombocytopenia, or known hypersensitivity to reviparin sodium or to any of its components. It should be used with caution in patients with a high risk of bleeding, such as those with severe hypertension, peptic ulcer disease, or recent brain, spinal, or ophthalmic surgery.<br />
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==Dosage and Administration==<br />
The dosage of reviparin sodium is individualized based on the patient's weight, indication, and renal function. It is administered subcutaneously, usually once or twice daily. <br />
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==See Also==<br />
* [[Low molecular weight heparin]]<br />
* [[Anticoagulant]]<br />
* [[Deep vein thrombosis]]<br />
* [[Pulmonary embolism]]<br />
* [[Heparin]]<br />
* [[Factor Xa]]<br />
* [[Thrombin]]<br />
* [[Fibrin]]<br />
* [[Hemodialysis]]<br />
* [[Thrombocytopenia]]<br />
* [[Osteoporosis]]<br />
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[[Category:Drugs]]<br />
[[Category:Anticoagulants]]<br />
[[Category:Low molecular weight heparins]]<br />
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{{Pharma-stub}}</div>Prab