https://wikimd.org/index.php?action=history&feed=atom&title=Retinoid_X_receptor_alphaRetinoid X receptor alpha - Revision history2026-04-26T22:42:57ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Retinoid_X_receptor_alpha&diff=5379488&oldid=prevPrab: CSV import2024-03-10T06:28:15Z<p>CSV import</p>
<p><b>New page</b></p><div>'''Retinoid X receptor alpha''' ('''RXR-alpha'''), also known as '''NR2B1''' (nuclear receptor subfamily 2, group B, member 1), is a nuclear receptor that in humans is encoded by the RXRA gene. RXR-alpha belongs to the family of [[nuclear receptor]]s and is involved in mediating the effects of [[retinoic acid]], a metabolite of [[vitamin A]] that plays key roles in cell growth and differentiation.<br />
<br />
== Structure ==<br />
The RXR-alpha protein has a modular structure and contains several functional domains. The A/B domain at the N-terminus contains a ligand-independent activation function (AF-1), while the C domain, also known as the DNA-binding domain (DBD), is responsible for binding to specific DNA sequences known as [[hormone response element]]s (HREs). The D domain, or hinge region, connects the DBD to the E/F domain, which contains the ligand-binding domain (LBD) and a ligand-dependent activation function (AF-2).<br />
<br />
== Function ==<br />
RXR-alpha forms heterodimers with several other nuclear receptors, including [[peroxisome proliferator-activated receptor]]s (PPARs), [[vitamin D receptor]] (VDR), and [[thyroid hormone receptor]] (TR). These heterodimers bind to specific DNA sequences and regulate the transcription of target genes. RXR-alpha is also capable of forming homodimers that bind to DNA and regulate gene expression.<br />
<br />
In addition to its role in gene regulation, RXR-alpha also plays a role in cell differentiation and apoptosis. It is involved in the regulation of [[lipid metabolism]], [[glucose metabolism]], and [[inflammation]], and has been implicated in several diseases, including [[cancer]], [[diabetes]], and [[atherosclerosis]].<br />
<br />
== Clinical significance ==<br />
Alterations in the function of RXR-alpha have been associated with several diseases. For example, mutations in the RXRA gene have been linked to [[leukemia]] and [[lung cancer]]. In addition, abnormal expression of RXR-alpha has been observed in [[breast cancer]], [[prostate cancer]], and [[colorectal cancer]].<br />
<br />
== See also ==<br />
* [[Retinoid X receptor]]<br />
* [[Nuclear receptor]]<br />
* [[Retinoic acid]]<br />
<br />
== References ==<br />
<references /><br />
<br />
[[Category:Genes]]<br />
[[Category:Nuclear receptors]]<br />
[[Category:Transcription factors]]<br />
{{medicine-stub}}</div>Prab