https://wikimd.org/index.php?action=history&feed=atom&title=Reserpine 2026-05-10T17:28:36Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Reserpine&diff=4967156&oldid=prev 2023-09-07T05:27:55Z

<p></p> <p><b>New page</b></p><div>{{intro}}<br /> [[File:Reserpine 200.svg|Reserpine|thumb]]<br /> Reserpine is an oral [[antihypertensive]] medication that acts through inhibitor of alpha-adrenergic transmission and was one of the first [[antihypertensive]] agents introduced into clinical practice.<br /> {{livtox}}<br /> Despite widescale use for many years, reserpine has not been shown to cause clinically apparent liver injury.<br /> <br /> {{moa}}<br /> Reserpine (re ser&#039; peen) was one of the first [[antihypertensive]] agents developed for use in humans. It is an alkaloid extract of the Rauwolifia serpentine (thus its name) which is a climbing shrub found in India. Reserpine is thought to act by binding to adrenergic storage vesicles in neurons, inhibiting their capacity to concentrate and store norepinephrine and dopamine. The [[antihypertensive]] effect of reserpine correlates with the depletion of sympathetic amines in both the central nervous system and periphery. Reserpine is effective in lowering [[blood pressure]] and can be used alone or in combination with other [[antihypertensive]] medications.<br /> <br /> {{fda}}<br /> Reserpine was approved for use in the United States in 1955 but is currently rarely used, largely because of its central nervous system effects and the availability of many better tolerated and more potent [[antihypertensive]] medications.<br /> <br /> {{dose}}<br /> Reserpine continues to be available in generic forms as tablets of 0.1 and 0.25 mg. The typical maintenance dose in adults is 0.05 to 0.25 mg once daily.<br /> <br /> {{se}}<br /> Side effects are common and include [[sedation]], difficulty concentrating, [[fatigue]], [[depression]], [[dry mouth]], [[headaches]], [[dizziness]], [[postural hypotension]], [[male impotence]] and [[gastrointestinal upset]].<br /> {{antihypertensives}}<br /> {{coststubd}}<br /> [[Category:Indole alkaloids]]<br /> [[Category:Alkaloids found in Rauvolfia]]<br /> [[Category:VMAT inhibitors]]<br /> [[Category:Depressogenics]]<br /> [[Category:Antihypertensive agents]]<br /> [[Category:Fetotoxins]]<br /> [[Category:Phenol ethers]]<br /> [[Category:Benzoates]]</div>

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