https://wikimd.org/index.php?action=history&feed=atom&title=ReprimoReprimo - Revision history2026-04-25T05:27:28ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Reprimo&diff=5291491&oldid=prevPrab: CSV import2024-02-25T15:24:16Z<p>CSV import</p>
<p><b>New page</b></p><div>'''Reprimo''' is a [[gene]] that in humans is encoded by the RPRM gene. This gene is a potential [[tumor suppressor]] and is a major mediator of the [[p53]]/TP53 tumor suppressor pathway. As a [[DNA damage]] inducible gene, it is involved in the induction of [[G2/M]] arrest.<br />
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== Function ==<br />
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The protein encoded by the Reprimo gene is a [[cytoplasmic]] protein, which is capable of inducing [[cell cycle]] arrest in G2/M phase. This protein is a DNA damage-inducible gene and may play a role in the cellular response to DNA damage. It is also suggested to function as a tumor suppressor.<br />
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== Clinical significance ==<br />
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Alterations in the Reprimo gene are associated with [[gastric cancer]]. The gene is frequently silenced in gastric cancer due to [[promoter hypermethylation]], and this silencing is associated with tumor progression.<br />
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== See also ==<br />
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* [[p53]]<br />
* [[Tumor suppressor]]<br />
* [[Gastric cancer]]<br />
* [[DNA damage]]<br />
* [[Cell cycle]]<br />
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== References ==<br />
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<references /><br />
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== External links ==<br />
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* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=RPRM GeneCards: RPRM]<br />
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[[Category:Genes]]<br />
[[Category:Human proteins]]<br />
[[Category:Tumor suppressor genes]]<br />
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