https://wikimd.com/index.php?action=history&feed=atom&title=RepSox 2026-04-07T16:24:42Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=RepSox&diff=6335560&oldid=prev 2025-02-20T01:39:02Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:39, 20 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l28">Line 28:</td> <td colspan="2" class="diff-lineno">Line 28:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;gallery&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:RepSox Skeletal Structure.png|RepSox</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/gallery&gt;</ins></div></td></tr> </table>

Prab https://wikimd.com/index.php?title=RepSox&diff=5385446&oldid=prev 2024-03-10T22:38:52Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;RepSox&#039;&#039;&#039; is a small molecule inhibitor that has been identified as a potent inducer of [[embryonic stem cell]] (ESC) pluripotency. It is also known as E-616452 or SJN 2511. RepSox was first discovered in a screen for compounds that could replace [[Sox2]], a transcription factor necessary for maintaining ESC pluripotency. <br /> <br /> == Mechanism of Action ==<br /> <br /> RepSox acts by inhibiting the [[transforming growth factor beta]] (TGF-β) pathway. Specifically, it inhibits the [[ALK5]] receptor, a type I receptor of the TGF-β pathway. This inhibition leads to the suppression of [[Smad2]]/[[Smad3]] phosphorylation, which in turn promotes the expression of [[Nanog]], a key transcription factor in maintaining ESC pluripotency.<br /> <br /> == Applications in Regenerative Medicine ==<br /> <br /> The ability of RepSox to induce pluripotency has significant implications for [[regenerative medicine]]. It can be used to reprogram somatic cells into induced pluripotent stem cells (iPSCs) without the need for genetic manipulation. This is particularly useful in the generation of patient-specific iPSCs for disease modeling and cell therapy.<br /> <br /> == Safety and Toxicity ==<br /> <br /> While RepSox has shown promise in preclinical studies, its safety and toxicity profile in humans is not yet fully understood. Further studies are needed to evaluate the potential risks associated with its use.<br /> <br /> == See Also ==<br /> * [[Induced pluripotent stem cell]]<br /> * [[Sox2]]<br /> * [[Nanog]]<br /> * [[Transforming growth factor beta]]<br /> * [[ALK5]]<br /> * [[Smad2]]<br /> * [[Smad3]]<br /> <br /> [[Category:Stem cells]]<br /> [[Category:Regenerative medicine]]<br /> [[Category:Small molecule inhibitors]]<br /> [[Category:Inducers of pluripotency]]<br /> <br /> {{medicine-stub}}</div>

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