Deepika vegiraju: Created page with "== '''What is remimazolam?''' == Remimazolam (BYFAVO) for injection is a benzodiazepine indicated for the induction and maintenance of procedural sedation in adults u..."

2021-07-05T17:06:29Z

Created page with "== '''What is remimazolam?''' == Remimazolam (BYFAVO) for injection is a benzodiazepine indicated for the induction and maintenance of procedural sedation in adults u..."

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== '''What is remimazolam?''' ==
Remimazolam (BYFAVO) for injection is a [[benzodiazepine]] indicated for the induction and maintenance of procedural [[sedation]] in adults undergoing procedures lasting 30 minutes or less.

[[File:Remimazolam.svg|thumb]]

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== '''What are the uses of this medicine?''' ==

* This medicine is indicated for the induction and maintenance of procedural [[sedation]] in adults undergoing procedures '''lasting 30 minutes or less'''.

== '''How does this medicine work?''' ==

* BYFAVO is a [[benzodiazepine]].
* BYFAVO '''binds to brain benzodiazepine sites (gamma amino butyric acid type A [GABAA] receptors)''', while its carboxylic acid metabolite (CNS7054) has a 300 times lower affinity for the receptor.
* BYFAVO, like other benzodiazepines, did not show clear selectivity between subtypes of the GABAA receptor.

== '''Who Should Not Use this medicine ?''' ==

This medicine cannot be used in patients with:
* In patients with a history of severe [[hypersensitivity]] reaction to dextran 40 or products containing dextran 40.

== '''What drug interactions can this medicine cause?''' ==

This medicine cannot be co administered with CNS depressant medications, including [[opioid analgesics]], other [[benzodiazepines]], and [[propofol]]. Continuously monitor vital signs during sedation and through the recovery period.

== '''Is this medicine FDA approved?''' ==

* It was approved for use in the United States in 2020.

== '''How should this medicine be used?''' ==

* Each single-patient-use vial contains 20 mg BYFAVO [[lyophilized]] powder for [[reconstitution]].
* The product must be prepared immediately before use.
* To reconstitute, add 8.2 mL sterile 0.9% Sodium Chloride Injection, USP, to the vial, directing the stream of solution toward the wall of the vial.
* Gently swirl the vial (do not shake) until the contents are fully dissolved.
* The reconstituted product will deliver a final concentration of 2.5 mg/mL solution of BYFAVO.

'''Adult Patients:'''
* Administer an initial dose intravenously as a 5 mg push injection over a 1-minute time period.
* If necessary, administer supplemental doses of 2.5 mg intravenously over a 15-second time period.
* At least 2 minutes must elapse prior to the administration of any supplemental dose.

'''ASA III-IV Patients:'''
* Based on the general condition of the patient, administer 2.5 mg to 5 mg over 1-minute time period.
* If necessary, administer supplemental doses of 1.25 mg to 2.5 mg intravenously over a 15-second time period.
* At least 2 minutes must elapse prior to the administration of any supplemental dose.

== '''What are the dosage forms and brand names of this medicine?''' ==

This medicine is available in fallowing doasage form:
'''As single-patient-use vial:''' Each glass, single-patient-use vial of BYFAVO (remimazolam) for injection contains 20 mg remimazolam.

This medicine is available in fallowing brand namesː
* '''BYFAVO'''

=='''What side effects can this medication cause?'''==

Common possible side effects of this medicine include:
* hypotension
* hypertension
* diastolic hypertension
* systolic hypertension
* hypoxia
* diastolic hypotension

==''' What special precautions should I follow?''' ==

* Hypersensitivity reactions including [[anaphylaxis]] may occur.
* [[Benzodiazepine]] use during pregnancy can result in neonatal sedation.
* Observe newborns for signs of sedation and manage accordingly.
* Weigh benefits against potential risks when considering elective procedures in children under 3 years old.
* since this medicine may cause pediatric Neurotoxicity.

== '''What to do in case of emergency/overdose?''' ==
Overdose of this medicine may lead to [[CNS depression]], associated with drowsiness, confusion, and lethargy, with possible progression to [[ataxia]], [[respiratory depression]], and [[hypotension]].

'''Management for overdosage:'''
* [[Flumazenil]] is indicated for the reversal of the [[sedative]] effects of [[benzodiazepines]] and may be used in situations when an overdose with BYFAVO is known or suspected.
* Flumazenil will only reverse benzodiazepine-induced effects and will not reverse the effects of other medications, such as [[opioid]] [[analgesics]].
* Monitor patients treated with flumazenil for re-sedation, [[respiratory depression]], and other residual benzodiazepine effects.
* Re-sedation by BYFAVO has not been observed after administration of flumazenil in clinical trials.

== '''Can this medicine be used in pregnancy?''' ==

* Infants born to mothers using benzodiazepines during the later stages of pregnancy have been reported to experience symptoms of sedation.
* Benzodiazepines cross the placenta and may produce [[respiratory depression]] and [[sedation]] in neonates.

=='''Can this medicine be used in children?'''==

* Safety and effectiveness in pediatric patients have not been established.

== '''What should I know about storage and disposal of this medication?''' ==

* Store at controlled room temperature 20°C to 25°C (68°F to 77°F) excursions between 15° and 30°C (59° and 86°F) are allowed.
* Reconstituted BYFAVO can be stored in the vial for up to 8 hours under controlled room temperature at 20°C to 25°C (68°F to 77°F).
* Protect vials from light once they are removed from packaging.
* Discard unused portion.

{{Benzodiazepines}}
{{GABAAR PAMs}}
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[[Category:GABAA receptor positive allosteric modulators]]
[[Category:Imidazobenzodiazepines]]
[[Category:Pyridines]]
[[Category:Bromoarenes]]
[[Category:Methyl esters]]
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Remimazolam - Revision history

Deepika vegiraju: Created page with "== '''What is remimazolam?''' == Remimazolam (BYFAVO) for injection is a benzodiazepine indicated for the induction and maintenance of procedural sedation in adults u..."