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	[[File:Histopathology_of_reactive_gastropathy,_annotated.jpg\|Histopathology of reactive gastropathy, annotated\|thumb]] '''Reactive gastropathy''', also known as '''chemical gastropathy''', is a condition of the [[stomach]] characterized by changes in the [[stomach lining]] (gastric mucosa) due to chronic exposure to irritants, such as [[nonsteroidal anti-inflammatory drugs]] (NSAIDs), [[alcohol]], or [[bile reflux]]. Unlike other forms of [[gastrointestinal disorders]], reactive gastropathy is not caused by infection with [[Helicobacter pylori]].		{{SI}}
			{{Infobox medical condition
			\| name = Reactive gastropathy
			\| image = [[File:Reactive_gastropathy_-_intermed_mag.jpg\|left\|thumb\|Reactive gastropathy under a microscope]]
			\| caption = Histological image of reactive gastropathy
			\| field = [[Gastroenterology]]
			\| symptoms = [[Nausea]], [[vomiting]], [[abdominal pain]]
			\| complications = [[Gastric ulcer]], [[bleeding]]
			\| onset = Variable
			\| duration = Chronic
			\| causes = [[Bile reflux]], [[nonsteroidal anti-inflammatory drugs]] (NSAIDs)
			\| risks = [[NSAID]] use, [[bile reflux]]
			\| diagnosis = [[Endoscopy]], [[biopsy]]
			\| differential = [[Gastritis]], [[peptic ulcer disease]]
			\| prevention = Avoidance of NSAIDs, management of bile reflux
			\| treatment = [[Proton pump inhibitors]], [[H2 receptor antagonists]]
			\| medication = [[Proton pump inhibitors]], [[H2 receptor antagonists]]
			\| prognosis = Generally good with treatment
			\| frequency = Common in patients using NSAIDs
			}}
			[[File:Histopathology_of_reactive_gastropathy,_annotated.jpg\|Histopathology of reactive gastropathy, annotated\|left\|thumb]] '''Reactive gastropathy''', also known as '''chemical gastropathy''', is a condition of the [[stomach]] characterized by changes in the [[stomach lining]] (gastric mucosa) due to chronic exposure to irritants, such as [[nonsteroidal anti-inflammatory drugs]] (NSAIDs), [[alcohol]], or [[bile reflux]]. Unlike other forms of [[gastrointestinal disorders]], reactive gastropathy is not caused by infection with [[Helicobacter pylori]].
	==Causes and Pathophysiology==		==Causes and Pathophysiology==
	Reactive gastropathy is primarily caused by the chronic use of NSAIDs, which inhibit the production of [[prostaglandins]], substances that help protect the stomach lining from the acidic environment of the stomach. Other causes include excessive alcohol consumption, [[bile reflux]], and physical stress from critical illness or surgery. The condition results from the stomach's exposure to these irritants, leading to mucosal damage characterized by edema, vascular congestion, and foveolar hyperplasia without significant inflammation or [[atrophy]].		Reactive gastropathy is primarily caused by the chronic use of NSAIDs, which inhibit the production of [[prostaglandins]], substances that help protect the stomach lining from the acidic environment of the stomach. Other causes include excessive alcohol consumption, [[bile reflux]], and physical stress from critical illness or surgery. The condition results from the stomach's exposure to these irritants, leading to mucosal damage characterized by edema, vascular congestion, and foveolar hyperplasia without significant inflammation or [[atrophy]].

	==Symptoms==		==Symptoms==
	The symptoms of reactive gastropathy can vary but often include [[dyspepsia]] (indigestion), [[nausea]], and sometimes [[vomiting]] or [[abdominal pain]]. Many individuals, however, may remain asymptomatic.		The symptoms of reactive gastropathy can vary but often include [[dyspepsia]] (indigestion), [[nausea]], and sometimes [[vomiting]] or [[abdominal pain]]. Many individuals, however, may remain asymptomatic.

	==Diagnosis==		==Diagnosis==
	Diagnosis of reactive gastropathy is typically made through [[endoscopy]], where characteristic changes in the gastric mucosa can be visualized. These changes include a smooth, reddened mucosa with visible vessels. [[Biopsy]] and histological examination of the gastric tissue can confirm the diagnosis, showing the hallmark features of foveolar hyperplasia, edema, and minimal inflammation.		Diagnosis of reactive gastropathy is typically made through [[endoscopy]], where characteristic changes in the gastric mucosa can be visualized. These changes include a smooth, reddened mucosa with visible vessels. [[Biopsy]] and histological examination of the gastric tissue can confirm the diagnosis, showing the hallmark features of foveolar hyperplasia, edema, and minimal inflammation.

	==Treatment==		==Treatment==
	The primary treatment for reactive gastropathy involves removing or reducing the exposure to the causative agent, such as discontinuing or lowering the dose of NSAIDs. In cases where NSAIDs cannot be discontinued, [[proton pump inhibitors]] (PPIs) or [[H2 receptor antagonists]] may be prescribed to reduce stomach acid production and promote healing of the gastric mucosa. Lifestyle modifications, including reducing alcohol consumption and avoiding spicy or acidic foods, may also help manage symptoms.		The primary treatment for reactive gastropathy involves removing or reducing the exposure to the causative agent, such as discontinuing or lowering the dose of NSAIDs. In cases where NSAIDs cannot be discontinued, [[proton pump inhibitors]] (PPIs) or [[H2 receptor antagonists]] may be prescribed to reduce stomach acid production and promote healing of the gastric mucosa. Lifestyle modifications, including reducing alcohol consumption and avoiding spicy or acidic foods, may also help manage symptoms.

	==Prevention==		==Prevention==
	Prevention of reactive gastropathy focuses on minimizing the use of NSAIDs and other known irritants. For individuals who require NSAID therapy, co-prescription of PPIs or the use of selective COX-2 inhibitors, which have a lower risk of causing gastric mucosal damage, may be considered.		Prevention of reactive gastropathy focuses on minimizing the use of NSAIDs and other known irritants. For individuals who require NSAID therapy, co-prescription of PPIs or the use of selective COX-2 inhibitors, which have a lower risk of causing gastric mucosal damage, may be considered.

	==See Also==		==See Also==
	* [[Gastritis]]		* [[Gastritis]]
	* [[Peptic ulcer disease]]		* [[Peptic ulcer disease]]
	* [[Gastroesophageal reflux disease]]		* [[Gastroesophageal reflux disease]]

	[[Category:Gastroenterology]]		[[Category:Gastroenterology]]
	[[Category:Stomach disorders]]		[[Category:Stomach disorders]]

	{{medicine-stub}}		{{medicine-stub}}

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2024-04-21T14:19:12Z

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[[File:Histopathology_of_reactive_gastropathy,_annotated.jpg|Histopathology of reactive gastropathy, annotated|thumb]] '''Reactive gastropathy''', also known as '''chemical gastropathy''', is a condition of the [[stomach]] characterized by changes in the [[stomach lining]] (gastric mucosa) due to chronic exposure to irritants, such as [[nonsteroidal anti-inflammatory drugs]] (NSAIDs), [[alcohol]], or [[bile reflux]]. Unlike other forms of [[gastrointestinal disorders]], reactive gastropathy is not caused by infection with [[Helicobacter pylori]].

==Causes and Pathophysiology==
Reactive gastropathy is primarily caused by the chronic use of NSAIDs, which inhibit the production of [[prostaglandins]], substances that help protect the stomach lining from the acidic environment of the stomach. Other causes include excessive alcohol consumption, [[bile reflux]], and physical stress from critical illness or surgery. The condition results from the stomach's exposure to these irritants, leading to mucosal damage characterized by edema, vascular congestion, and foveolar hyperplasia without significant inflammation or [[atrophy]].

==Symptoms==
The symptoms of reactive gastropathy can vary but often include [[dyspepsia]] (indigestion), [[nausea]], and sometimes [[vomiting]] or [[abdominal pain]]. Many individuals, however, may remain asymptomatic.

==Diagnosis==
Diagnosis of reactive gastropathy is typically made through [[endoscopy]], where characteristic changes in the gastric mucosa can be visualized. These changes include a smooth, reddened mucosa with visible vessels. [[Biopsy]] and histological examination of the gastric tissue can confirm the diagnosis, showing the hallmark features of foveolar hyperplasia, edema, and minimal inflammation.

==Treatment==
The primary treatment for reactive gastropathy involves removing or reducing the exposure to the causative agent, such as discontinuing or lowering the dose of NSAIDs. In cases where NSAIDs cannot be discontinued, [[proton pump inhibitors]] (PPIs) or [[H2 receptor antagonists]] may be prescribed to reduce stomach acid production and promote healing of the gastric mucosa. Lifestyle modifications, including reducing alcohol consumption and avoiding spicy or acidic foods, may also help manage symptoms.

==Prevention==
Prevention of reactive gastropathy focuses on minimizing the use of NSAIDs and other known irritants. For individuals who require NSAID therapy, co-prescription of PPIs or the use of selective COX-2 inhibitors, which have a lower risk of causing gastric mucosal damage, may be considered.

==See Also==
* [[Gastritis]]
* [[Peptic ulcer disease]]
* [[Gastroesophageal reflux disease]]

[[Category:Gastroenterology]]
[[Category:Stomach disorders]]

{{medicine-stub}}

Reactive gastropathy - Revision history

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