https://wikimd.org/index.php?action=history&feed=atom&title=RadiosensitivityRadiosensitivity - Revision history2026-04-26T05:59:52ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Radiosensitivity&diff=5278863&oldid=prevPrab: CSV import2024-02-25T03:31:18Z<p>CSV import</p>
<p><b>New page</b></p><div>'''Radiosensitivity''' refers to the relative susceptibility of cells, tissues, organs or organisms to the harmful effect of [[radiation]]. It is a significant concept in [[radiobiology]] and [[radiation therapy]].<br />
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== Overview ==<br />
Radiosensitivity is determined by a number of factors, including the rate of cell division, the type of tissue, and the stage of cell cycle. Cells that are rapidly dividing, such as [[cancer]] cells, are generally more radiosensitive than cells that are not. Similarly, tissues that have a high rate of cell turnover, such as the [[skin]] and the lining of the [[gastrointestinal tract]], are more radiosensitive than tissues with a low rate of cell turnover, such as muscle and nerve tissue.<br />
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== Factors affecting radiosensitivity ==<br />
Several factors can affect the radiosensitivity of a cell or tissue. These include:<br />
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* '''Cell cycle:''' Cells are most radiosensitive in the late G2 and M phases of the cell cycle, and least radiosensitive in the late S phase.<br />
* '''Oxygen effect:''' The presence of oxygen in a cell can increase its radiosensitivity, a phenomenon known as the oxygen effect.<br />
* '''Repair capacity:''' Cells with a high capacity for DNA repair are less radiosensitive than cells with a low repair capacity.<br />
* '''Genetic factors:''' Certain genetic conditions, such as [[Ataxia telangiectasia]] and [[Nijmegen breakage syndrome]], are associated with increased radiosensitivity.<br />
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== Radiosensitivity and cancer treatment ==<br />
In the context of cancer treatment, radiosensitivity is a critical factor in the success of radiation therapy. Tumors that are highly radiosensitive, such as [[lymphomas]] and [[seminomas]], can often be effectively treated with radiation. Conversely, tumors that are radioresistant, such as [[melanomas]] and [[sarcomas]], are less likely to respond to radiation therapy.<br />
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== See also ==<br />
* [[Radioresistance]]<br />
* [[Radiobiology]]<br />
* [[Radiation therapy]]<br />
* [[DNA repair]]<br />
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== References ==<br />
<references /><br />
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[[Category:Radiobiology]]<br />
[[Category:Radiation therapy]]<br />
[[Category:Cancer treatment]]<br />
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