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<p><b>New page</b></p><div>'''RUNX1T1''' (also known as '''Runt-related transcription factor 1; translocated to, 1''') is a gene that encodes a nuclear protein in humans. This protein is a member of the [[E26 transformation-specific (ETS) family of transcription factors]] and is involved in the regulation of [[gene expression]]. <br />
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== Function ==<br />
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The RUNX1T1 gene is located on the long (q) arm of [[chromosome 8]] at position 21. The protein encoded by this gene is a member of the myeloid translocation gene (MTG) family. These proteins are transcriptional corepressors that play a role in hematopoiesis, the process by which blood cells are formed. <br />
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The RUNX1T1 protein interacts with a variety of other proteins, including the [[core-binding factor (CBF)]] and [[E2F1]], to regulate gene expression. It is thought to play a role in the development of certain types of leukemia when it is fused with the [[RUNX1]] gene due to a chromosomal translocation.<br />
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== Clinical significance ==<br />
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Mutations in the RUNX1T1 gene have been associated with a variety of hematological disorders, including [[acute myeloid leukemia (AML)]]. In particular, a translocation between chromosomes 8 and 21, which results in a fusion between the RUNX1 and RUNX1T1 genes, is one of the most common genetic abnormalities in AML. This fusion gene produces a protein that can disrupt normal blood cell development and lead to leukemia.<br />
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== Research ==<br />
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Research into the RUNX1T1 gene and its associated proteins is ongoing, with a focus on understanding its role in normal blood cell development and in the pathogenesis of leukemia. This research may lead to new treatments for leukemia and other hematological disorders.<br />
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== See also ==<br />
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* [[Gene]]<br />
* [[Transcription factor]]<br />
* [[Leukemia]]<br />
* [[Hematopoiesis]]<br />
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== References ==<br />
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{{Reflist}}<br />
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[[Category:Genes]]<br />
[[Category:Transcription factors]]<br />
[[Category:Hematology]]<br />
[[Category:Oncology]]<br />
{{gene-stub}}<br />
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