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			== RNA_splicing ==
			<gallery>
			File:Process_of_RNA_splicing.png\|Process of RNA splicing
			File:Intron_miguelferig.jpg\|Intron
			File:RNA_splicing_reaction.svg\|RNA splicing reaction
			</gallery>

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'''RNA splicing''' is a process that occurs in the [[cell nucleus]] after [[transcription]], and prior to [[translation]]. It involves the removal of [[introns]] and joining of [[exons]] in a pre-mRNA molecule. This process is crucial for the correct translation of the genetic code into proteins.

== Overview ==

RNA splicing is a modification of the [[RNA]] after transcription, in which the introns are removed and exons are joined. This is needed for the typical [[eukaryotic]] mRNA, but not for the [[prokaryotic]]. The process is also critical for the unification of the genetic code and for the capacity to generate multiple proteins from a single gene.

== Process ==

The process of RNA splicing involves several steps. First, the pre-mRNA is cleaved at the 5' splice site. This is followed by the formation of a lariat structure, which is then cleaved at the 3' splice site. Finally, the exons are ligated together.

== Spliceosome ==

The [[spliceosome]] is the cellular machinery that carries out RNA splicing. It is composed of five small nuclear ribonucleoproteins (snRNPs) and numerous other proteins. The spliceosome recognizes the splice sites of the pre-mRNA, carries out the splicing reaction, and then disassembles.

== Alternative splicing ==

[[Alternative splicing]] is a process that allows a single gene to produce multiple proteins. It does this by including or excluding certain exons in the final mRNA. This process is regulated by various splicing factors and can be influenced by external conditions.

== Clinical significance ==

Defects in RNA splicing are known to cause various diseases, including [[cancer]] and [[neurodegenerative diseases]]. Understanding the mechanisms of RNA splicing and its regulation can therefore have important implications for the development of new treatments.

== See also ==

* [[Gene expression]]
* [[Post-transcriptional modification]]
* [[RNA editing]]

[[Category:RNA]]
[[Category:Gene expression]]
[[Category:Molecular biology]]

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RNA splicing - Revision history

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