https://wikimd.com/index.php?action=history&feed=atom&title=RNASEH2A 2026-04-24T11:31:46Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=RNASEH2A&diff=5335507&oldid=prev 2024-02-29T17:29:06Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;RNASEH2A&#039;&#039;&#039; is a gene that encodes the Ribonuclease H2 subunit A protein in humans. This protein is a part of the [[Ribonuclease H]] family, which is responsible for the hydrolysis of RNA in DNA/RNA hybrids, playing a crucial role in DNA replication and repair.<br /> <br /> == Function ==<br /> <br /> The [[RNASEH2A]] gene provides instructions for making a protein that is one of three subunits of the Ribonuclease H2 (RNase H2) enzyme. This enzyme is involved in DNA replication and repair, and it helps maintain the integrity of the cell&#039;s genetic information. Specifically, RNase H2 is responsible for recognizing and removing ribonucleotides, which are the building blocks of RNA, that have been mistakenly incorporated into DNA molecules.<br /> <br /> == Clinical Significance ==<br /> <br /> Mutations in the [[RNASEH2A]] gene have been associated with [[Aicardi-Goutières syndrome]], a disorder that affects the brain, the immune system, and the skin. This condition is characterized by an early onset, often in infancy, and can cause severe physical and intellectual disability. Mutations in the RNASEH2A gene can also cause a form of systemic lupus erythematosus, an autoimmune disorder in which the body&#039;s immune system mistakenly attacks healthy tissues.<br /> <br /> == See Also ==<br /> <br /> * [[Ribonuclease H]]<br /> * [[Aicardi-Goutières syndrome]]<br /> * [[Systemic lupus erythematosus]]<br /> <br /> == References ==<br /> <br /> {{reflist}}<br /> <br /> [[Category:Genes]]<br /> [[Category:Human proteins]]<br /> [[Category:DNA replication]]<br /> [[Category:DNA repair]]<br /> {{gene-stub}}</div>

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