https://wikimd.org/index.php?action=history&feed=atom&title=RAF_kinaseRAF kinase - Revision history2026-04-26T21:54:01ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=RAF_kinase&diff=5787174&oldid=prevPrab: CSV import2024-05-16T03:33:24Z<p>CSV import</p>
<p><b>New page</b></p><div>[[File:MAPKpathway.jpg|thumb|MAPKpathway]] '''RAF Kinase'''<br />
RAF kinase is a family of serine/threonine-specific protein kinases that play a crucial role in the mitogen-activated protein kinase (MAPK) signaling pathway. This pathway is involved in regulating cell proliferation, differentiation, and survival. The RAF kinase family consists of three members: A-Raf, B-Raf, and C-Raf (also known as Raf-1).<br />
== Structure ==<br />
RAF kinases share a similar domain structure, including an N-terminal regulatory domain and a C-terminal kinase domain. The regulatory domain contains a Ras-binding domain (RBD) that interacts with activated Ras proteins, leading to the activation of RAF kinases. The kinase domain is responsible for phosphorylating downstream targets in the MAPK pathway.<br />
== Function ==<br />
Upon activation by Ras, RAF kinases phosphorylate and activate MEK (MAPK/ERK kinase), which in turn phosphorylates and activates ERK (extracellular signal-regulated kinase). Activated ERK translocates to the nucleus and phosphorylates various transcription factors, leading to the expression of genes involved in cell proliferation and survival.<br />
== Clinical Significance ==<br />
Mutations in RAF kinases have been implicated in various cancers, including melanoma and colorectal cancer. B-Raf mutations, in particular, are common in melanoma and have led to the development of targeted therapies such as vemurafenib and dabrafenib.<br />
== See also ==<br />
* [[Mitogen-activated protein kinase]]<br />
* [[MAPK/ERK pathway]]<br />
== References ==<br />
{{food-stub}}<br />
[[Category:Protein kinases]]<br />
[[Category:Cell signaling]]<br />
[[Category:Cancer research]]</div>Prab