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2024-02-24T10:49:05Z

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'''Pyrogen'''

A '''[[Pyrogen]]''' is a substance, typically produced by a [[bacteria]], that can cause a rise in [[body temperature]]. Pyrogens can be either exogenous or endogenous. [[Exogenous pyrogens]] are external to the body, often bacterial in origin, while [[endogenous pyrogens]] are produced by the body, typically in response to an infection or tissue damage.

==Types of Pyrogens==

===Exogenous Pyrogens===

Exogenous pyrogens are often bacterial products such as [[lipopolysaccharides]] (LPS). These substances can stimulate the body's immune cells to release substances that can affect the [[hypothalamus]] and raise body temperature.

===Endogenous Pyrogens===

Endogenous pyrogens are typically produced by the body's own immune cells in response to an infection or tissue damage. These include substances such as [[interleukin-1]] (IL-1), [[interleukin-6]] (IL-6), and [[tumor necrosis factor]] (TNF).

==Effects of Pyrogens==

When pyrogens bind to certain receptors in the body, they can trigger a cascade of events leading to a rise in body temperature. This is often part of the body's defense mechanism against infection, as the raised temperature can help to kill off invading pathogens.

==Detection and Removal==

Pyrogens can be detected in a variety of ways, including the [[Limulus amebocyte lysate]] (LAL) test, which uses blood from the horseshoe crab to detect bacterial endotoxins. Pyrogens can be removed from substances such as drugs and vaccines through a process known as [[depoyrogenation]].

==See Also==

* [[Fever]]
* [[Inflammation]]
* [[Sepsis]]

[[Category:Immunology]]
[[Category:Microbiology]]
[[Category:Pharmacology]]

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Pyrogen - Revision history

Prab: CSV import