Prab: CSV import

2025-02-13T03:45:45Z

CSV import

← Older revision		Revision as of 03:45, 13 February 2025
Line 1:		Line 1:
			== Pyrantel ==

	~~{{intro}}~~		[[File:Pyrantel.png\|thumb\|right\|Chemical structure of Pyrantel]]
	~~Praziquantel is an antihelmintic agent with activity against a broad spectrum~~ of ~~trematodes and cestodes that is used predominantly in the therapy of schistosomiasis, liver flukes, and cysticercosis.~~

	~~{{livtox}}~~		'''Pyrantel''' is an [[anthelmintic]] medication used to treat a variety of [[parasitic worm]] infections. It is particularly effective against [[hookworm]]s and [[roundworm]]s. Pyrantel works by paralyzing the worms, which are then expelled from the body through the [[feces]].
	~~Praziquantel therapy has been reported~~ to ~~cause serum aminotransferase elevations during therapy~~, ~~but clinically apparent liver injury after its use is rare if it occurs at all~~.

	~~{{moa}}~~		== Mechanism of Action ==
	~~Praziquantel (praz" i kown' tel) is~~ a ~~heterocyclic prazino-isoquinoline derivative with~~ a ~~broad spectrum of activity against several trematodes (Fasciola~~, ~~Schistosoma) and cestodes (Taenia). Praziquantel is believed~~ to ~~act by interference with tegument calcium transport, resulting in~~ paralysis of the ~~parasitic worms with subsequent loss of adherence~~ to ~~tissue, degradation and expulsion~~.		Pyrantel acts as a [[neuromuscular blocking agent]] in susceptible parasites. It causes a depolarizing neuromuscular blockade, leading to spastic paralysis of the worm. This paralysis allows the host's natural peristaltic action to expel the worm from the [[gastrointestinal tract]].

	~~{{fda}}~~		== Uses ==
	~~{{PAGENAME}} was approved for use in the United States in 1982 for schistosomiasis. Praziquantel~~ is ~~also~~ commonly used ~~in veterinary medicine.~~		Pyrantel is commonly used to treat infections caused by:
			* [[Enterobius vermicularis]] (pinworm)
			* [[Ascaris lumbricoides]] (roundworm)
			* [[Ancylostoma duodenale]] and [[Necator americanus]] (hookworms)

	~~{{dose}}~~		== Administration ==
	~~Praziquantel~~ is ~~available for human use~~ in ~~tablets~~ of ~~600 mg generically~~ and ~~under~~ the ~~brand name BiltricideThe typical dose for treating schistosomiasis in adults is 20 mg/kg (depending upon the species) three times over one day~~.		Pyrantel is administered orally, often in the form of a [[pyrantel pamoate]] suspension or tablet. The dosage is typically based on the patient's weight and the type of infection being treated.

	~~{{se}}~~		== Side Effects ==
	~~Side~~ effects are ~~common~~ but ~~transient, and~~ include ~~abdominal discomfort,~~ [[~~nausea~~]], [[~~vomiting~~]], ~~vertigo, muscle aches,~~ [[~~drowsiness~~]], [[~~headache~~]]s and ~~fatigue, some of the symptoms being due~~ to ~~its effects on the parasites~~.		Common side effects of pyrantel may include:
	~~{{antihelminthics}}~~		* [[Nausea]]
	~~{{coststubd}}~~		* [[Vomiting]]
			* [[Diarrhea]]
			* [[Abdominal cramps]]

			Serious side effects are rare but can include [[allergic reactions]] such as [[rash]], [[itching]], and [[swelling]].

			== Precautions ==
			Patients with [[liver disease]] should use pyrantel with caution. It is also important to follow the prescribed dosage and not to use pyrantel in combination with other anthelmintics unless directed by a healthcare provider.

			== Related Pages ==
			* [[Anthelmintic]]
			* [[Parasitic worm]]
			* [[Hookworm]]
			* [[Roundworm]]

			[[Category:Anthelmintics]]
			[[Category:Parasitic diseases]]

Prab: Created page with " {{intro}} Praziquantel is an antihelmintic agent with activity against a broad spectrum of trematodes and cestodes that is used predominantly in the therapy of schistosomiasi..."

2019-04-27T01:00:32Z

Created page with " {{intro}} Praziquantel is an antihelmintic agent with activity against a broad spectrum of trematodes and cestodes that is used predominantly in the therapy of schistosomiasi..."

New page

{{intro}}
Praziquantel is an antihelmintic agent with activity against a broad spectrum of trematodes and cestodes that is used predominantly in the therapy of schistosomiasis, liver flukes, and cysticercosis.

{{livtox}}
Praziquantel therapy has been reported to cause serum aminotransferase elevations during therapy, but clinically apparent liver injury after its use is rare if it occurs at all.

{{moa}}
Praziquantel (praz" i kown' tel) is a heterocyclic prazino-isoquinoline derivative with a broad spectrum of activity against several trematodes (Fasciola, Schistosoma) and cestodes (Taenia). Praziquantel is believed to act by interference with tegument calcium transport, resulting in paralysis of the parasitic worms with subsequent loss of adherence to tissue, degradation and expulsion.

{{fda}}
{{PAGENAME}} was approved for use in the United States in 1982 for schistosomiasis. Praziquantel is also commonly used in veterinary medicine.

{{dose}}
Praziquantel is available for human use in tablets of 600 mg generically and under the brand name BiltricideThe typical dose for treating schistosomiasis in adults is 20 mg/kg (depending upon the species) three times over one day.

{{se}}
Side effects are common but transient, and include abdominal discomfort, [[nausea]], [[vomiting]], vertigo, muscle aches, [[drowsiness]], [[headache]]s and fatigue, some of the symptoms being due to its effects on the parasites.
{{antihelminthics}}
{{coststubd}}

Pyrantel - Revision history

Prab: CSV import

Prab: Created page with " {{intro}} Praziquantel is an antihelmintic agent with activity against a broad spectrum of trematodes and cestodes that is used predominantly in the therapy of schistosomiasi..."