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<p><b>New page</b></p><div>[[File:Pseudotropine.svg|thumb|{{PAGENAME}}]]<br>'''Pseudotropine''' is an [[alkaloid]] that is a structural isomer of [[tropine]]. It is a secondary metabolite found in a variety of plants, including those in the [[Solanaceae]] family. Pseudotropine is also known as '''isotropine''' and has been used in the synthesis of various pharmaceuticals.<br />
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==Chemistry==<br />
Pseudotropine is a [[tropane alkaloid]], a class of alkaloids that also includes [[atropine]] and [[cocaine]]. It is a bicyclic compound, consisting of a six-membered [[piperidine]] ring fused to a five-membered [[pyrrolidine]] ring. The compound is chiral, with the natural form being the (R)-enantiomer.<br />
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==Biosynthesis==<br />
The biosynthesis of pseudotropine begins with the amino acids [[ornithine]] and [[arginine]], which are converted into [[putrescine]] by the enzyme [[ornithine decarboxylase]]. Putrescine is then converted into [[N-methylputrescine]] by the enzyme [[putrescine N-methyltransferase]]. N-methylputrescine is then oxidized to form [[N-methyl-Δ1-pyrroline]], which is then reduced to form [[tropinone]]. Tropinone is then rearranged to form pseudotropine by the enzyme [[tropinone reductase]].<br />
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==Pharmacology==<br />
Pseudotropine has been used as a starting material in the synthesis of various pharmaceuticals, including [[atropine]], [[scopolamine]], and [[hyoscyamine]]. These drugs are used to treat a variety of conditions, including [[gastrointestinal disorders]], [[motion sickness]], and certain [[eye diseases]].<br />
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==Toxicology==<br />
Like other tropane alkaloids, pseudotropine can be toxic if ingested in large amounts. Symptoms of overdose can include [[dry mouth]], [[blurred vision]], [[tachycardia]], and [[hallucinations]]. In severe cases, overdose can lead to [[coma]] or death.<br />
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==See also==<br />
* [[Tropane]]<br />
* [[Tropine]]<br />
* [[Atropine]]<br />
* [[Scopolamine]]<br />
* [[Hyoscyamine]]<br />
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[[Category:Alkaloids]]<br />
[[Category:Tropane alkaloids]]<br />
[[Category:Secondary metabolites]]<br />
[[Category:Pharmacology]]<br />
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