Prab: CSV import

2025-02-18T11:37:12Z

CSV import

← Older revision		Revision as of 11:37, 18 February 2025
Line 36:		Line 36:
	[[Category:Cell biology]]		[[Category:Cell biology]]
	[[Category:Protein targeting]]		[[Category:Protein targeting]]
			<gallery>
			File:Gunter_Blobel_2008_3.JPG\|Gunter Blobel, Nobel Prize winner for discoveries in protein targeting
			File:General_Overview_of_Protein_Targeting.png\|General overview of protein targeting
			File:Overview_of_proteins_targeted_to_the_mitochondira.png\|Overview of proteins targeted to the mitochondria
			File:Carrier_pathway_for_proteins_to_inner_membrane.png\|Carrier pathway for proteins to inner membrane
			File:Inner_membrane_and_matrix_protein_targeting.png\|Inner membrane and matrix protein targeting
			File:Protein_targeting_to_the_thylakoid_membrane_in_chloroplasts.png\|Protein targeting to the thylakoid membrane in chloroplasts
			File:Peroxisome_Protein_Targeting.png\|Peroxisome protein targeting
			</gallery>

Prab: CSV import

2024-02-25T09:07:40Z

CSV import

New page

'''Protein targeting''' or '''protein sorting''' is the biological mechanism by which proteins are transported to their correct destinations within or outside the cell. Proteins can be targeted to the [[inner cell]] or [[cell membrane]], [[organelles]] of the cell, or to exterior of the cell via [[secretion]].

== Overview ==

Protein targeting occurs post-[[translation]]ally for most proteins, although some proteins may be directed to specific locations while they are being synthesized (co-translationally). The targeting process is usually specified by the [[amino acid]] sequence of the protein itself, which can contain targeting signals for various cellular compartments.

== Mechanisms ==

=== Co-translational targeting ===

Co-translational targeting begins while the protein is still being synthesized. It is associated with proteins that are destined for the [[endoplasmic reticulum]], including those that will be secreted from the cell, and proteins that will reside in the [[plasma membrane]].

=== Post-translational targeting ===

Post-translational targeting occurs after the protein has been completely synthesized. It is associated with proteins that will reside in a number of different cellular compartments, including the [[mitochondria]], [[chloroplasts]], [[peroxisomes]], and the [[nucleus]].

== Protein targeting signals ==

Protein targeting signals, or signal sequences, are the "addresses" that direct proteins to their correct location. These are usually found at the beginning (N-terminus) of the protein sequence, but can also be found at the end (C-terminus), or internally.

== See also ==

* [[Signal peptide]]
* [[Signal recognition particle]]
* [[Translocon]]
* [[Sec61]]
* [[TOMM20]]
* [[TIMM23]]

== References ==

<references />

{{stub}}

[[Category:Cell biology]]
[[Category:Protein targeting]]

Protein targeting - Revision history

Prab: CSV import

Prab: CSV import