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	{{Cell-biology-stub}}		{{Cell-biology-stub}}
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			<gallery>
			File:Kinase_function.png\|Protein kinase function
			File:Inorganic-phosphate-3D-balls.png\|Inorganic phosphate 3D model
			File:CaMKII.png\|CaMKII structure
			</gallery>

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'''Protein Kinase'''

A '''[[Protein kinase]]''' is a type of [[enzyme]] that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). This process is a crucial aspect of [[cell signaling]] and regulates cellular activities such as [[protein-protein interaction]] and [[protein degradation]].

== Function ==

[[Protein kinases]] play a pivotal role in the regulation of many cellular processes including cell cycle, gene expression, and differentiation. They can become overactive or inactive in many types of cancer, and a number of inhibitors have been developed to control them.

== Classification ==

Protein kinases are classified into broad groups by the substrate they act on: [[serine/threonine-specific protein kinases]], [[tyrosine kinases]], and [[dual-specificity kinases]]. They can also be categorized by their function within the [[signal transduction]] pathways.

== Structure ==

The structure of protein kinases is largely conserved, with a small, generally N-terminal, lobe that binds [[adenosine triphosphate]] (ATP) and a large C-terminal lobe that binds the protein substrate. The two lobes are linked by a hinge region that aligns the lobes in the correct orientation.

== Clinical significance ==

Protein kinases have been identified as a cause of several diseases, such as [[cancer]], [[inflammation]], and [[neurodegenerative diseases]]. They are also the target of a number of pharmaceuticals, which inhibit their activity.

== See also ==
* [[Kinase]]
* [[Phosphorylation]]
* [[Signal transduction]]

== References ==
<references />

[[Category:Enzymes]]
[[Category:Cell biology]]
[[Category:Protein kinases]]
{{Enzymes}}
{{Cell-biology-stub}}
{{Biochem-stub}}

Protein kinase - Revision history

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