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← Older revision		Revision as of 11:34, 18 February 2025
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	[[Category:Metabolism]]		[[Category:Metabolism]]
	[[Category:Coenzymes]]		[[Category:Coenzymes]]
			<gallery>
			File:Propionyl-Coenzyme_A.png\|Propionyl-Coenzyme A structure
			File:Odd-chain_FA_oxydation.png\|Odd-chain fatty acid oxidation
			File:Nihms213291f1.jpg\|Propionyl-CoA
			File:Methylcitrate_Cycle_with_Intermediates_and_Enzymes.png\|Methylcitrate cycle with intermediates and enzymes
			File:3-hydroxypropionic-acid-3D-balls.png\|3-Hydroxypropionic acid 3D model
			File:Aspergillus_nidulans.jpg\|Aspergillus nidulans
			File:5H84_as_recorded_by_PYMOL_from_the_Protein_Data_Bank.png\|5H84 structure from the Protein Data Bank
			</gallery>

Prab: CSV import

2024-02-29T18:09:11Z

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'''Propionyl-CoA''' is a significant intermediate in the metabolic pathway known as the [[tricarboxylic acid cycle]] (TCA cycle) or Krebs cycle. It is derived from the catabolism of odd-chain fatty acids, branched-chain amino acids, and from the side chain of cholesterol.

== Structure ==
Propionyl-CoA is a [[Coenzyme A]] (CoA) derivative in which the terminal sulfhydryl group (-SH) is linked to the carboxyl group (-COOH) of propionic acid through a high-energy thioester bond. The molecule is composed of an adenosine 3',5'-bisphosphate moiety, a pantothenic acid moiety, and a cysteamine moiety.

== Metabolism ==
Propionyl-CoA is metabolized in a series of reactions known as the [[propionyl-CoA carboxylase]] pathway. This pathway converts propionyl-CoA to [[methylmalonyl-CoA]], which is then converted to [[succinyl-CoA]], a key intermediate in the TCA cycle. The conversion of propionyl-CoA to succinyl-CoA requires several enzymes and cofactors, including [[biotin]], [[adenosylcobalamin]], and [[methylmalonyl-CoA mutase]].

== Clinical significance ==
Defects in the metabolism of propionyl-CoA can lead to several metabolic disorders, including [[propionic acidemia]] and [[methylmalonic acidemia]]. These disorders are characterized by the accumulation of propionyl-CoA and its metabolites in the body, leading to various symptoms such as developmental delay, intellectual disability, and metabolic acidosis.

== See also ==
* [[Coenzyme A]]
* [[Tricarboxylic acid cycle]]
* [[Propionic acidemia]]
* [[Methylmalonic acidemia]]

{{Biochemistry-stub}}
[[Category:Biochemistry]]
[[Category:Metabolism]]
[[Category:Coenzymes]]

Propionyl-CoA - Revision history

Prab: CSV import

Prab: CSV import