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<p><b>New page</b></p><div>[[File:Properidine.svg|thumb|{{PAGENAME}}]]<br>'''Properidine''' is a synthetic [[opioid]] and is part of the [[piperidine]] class of analgesic agents. It is primarily used in the management of moderate to severe pain. Properidine is also known by its trade name, '''Rhotral''', and is classified as a Schedule I drug under the [[Controlled Substances Act]] in the United States.<br />
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==Pharmacology==<br />
Properidine acts as a [[mu-opioid receptor]] agonist. This receptor is a G protein-coupled receptor that mediates the effects of opioids. When properidine binds to the mu-opioid receptor, it inhibits the release of [[GABA]], a neurotransmitter that inhibits the release of dopamine. This results in an increase in [[dopamine]] release, which contributes to the analgesic effects of the drug.<br />
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==Clinical Use==<br />
Properidine is used for the management of moderate to severe pain. It is often used in situations where other analgesics, such as [[nonsteroidal anti-inflammatory drugs]] (NSAIDs) or [[paracetamol]], are not effective. Properidine can be administered orally, intramuscularly, or intravenously.<br />
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==Side Effects==<br />
Like other opioids, properidine has a number of side effects. These can include [[nausea]], [[vomiting]], [[constipation]], and [[respiratory depression]]. In addition, properidine can cause [[physical dependence]] and [[withdrawal]] symptoms if used for a prolonged period of time.<br />
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==Legal Status==<br />
In the United States, properidine is classified as a Schedule I drug under the Controlled Substances Act. This means that it has a high potential for abuse and no accepted medical use. In other countries, the legal status of properidine may vary.<br />
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==See Also==<br />
* [[Opioid]]<br />
* [[Piperidine]]<br />
* [[Controlled Substances Act]]<br />
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[[Category:Opioids]]<br />
[[Category:Piperidines]]<br />
[[Category:Analgesics]]<br />
{{Opioids}}<br />
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