https://wikimd.org/index.php?action=history&feed=atom&title=Prodipine 2026-04-24T23:11:49Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Prodipine&diff=6428361&oldid=prev 2025-03-05T06:30:33Z

<p>CSV import</p> <p><b>New page</b></p><div>{{Short description|A calcium channel blocker}}<br /> {{Drugbox<br /> | verifiedfields = changed<br /> | verifiedrevid = 477318123<br /> | IUPAC_name = 3,5-dimethyl-2-phenyl-4-(3-phenylpropyl)-1,4-dihydropyridine-3,5-dicarboxylate<br /> | image = Prodipine.svg<br /> | image_size = 200px<br /> | image_alt = Chemical structure of Prodipine<br /> }}<br /> <br /> &#039;&#039;&#039;Prodipine&#039;&#039;&#039; is a [[calcium channel blocker]] of the [[dihydropyridine]] class. It is primarily used in the management of [[hypertension]] and [[angina pectoris]].<br /> <br /> ==Pharmacology==<br /> Prodipine functions by inhibiting the influx of calcium ions through [[L-type calcium channels]] in the [[smooth muscle]] cells of the [[vascular system]]. This action results in the relaxation of vascular smooth muscle, leading to [[vasodilation]] and a subsequent decrease in [[blood pressure]].<br /> <br /> ===Mechanism of Action===<br /> [[File:Prodipine.svg|Chemical structure of Prodipine|thumb|right]]<br /> The primary mechanism of action of Prodipine involves the blockade of L-type calcium channels. By preventing calcium ions from entering the cells, Prodipine reduces the contractility of the heart muscle and dilates the arteries. This reduces the workload on the heart and lowers blood pressure, making it effective in treating hypertension and angina.<br /> <br /> ===Pharmacokinetics===<br /> Prodipine is well absorbed from the [[gastrointestinal tract]] and undergoes extensive [[first-pass metabolism]] in the [[liver]]. It is metabolized primarily by the [[cytochrome P450]] enzyme system. The metabolites are excreted mainly in the urine.<br /> <br /> ==Clinical Use==<br /> Prodipine is indicated for the treatment of hypertension and chronic stable angina. It may be used alone or in combination with other antihypertensive agents. The drug is typically administered orally.<br /> <br /> ===Side Effects===<br /> Common side effects of Prodipine include [[headache]], [[dizziness]], [[flushing]], and [[peripheral edema]]. These effects are generally mild and transient. Serious side effects are rare but may include [[hypotension]] and [[bradycardia]].<br /> <br /> ==Contraindications==<br /> Prodipine is contraindicated in patients with known hypersensitivity to dihydropyridines. Caution is advised in patients with severe [[aortic stenosis]], [[heart failure]], or [[hepatic impairment]].<br /> <br /> ==Related pages==<br /> * [[Calcium channel blocker]]<br /> * [[Hypertension]]<br /> * [[Angina pectoris]]<br /> * [[Dihydropyridine]]<br /> <br /> [[Category:Calcium channel blockers]]<br /> [[Category:Dihydropyridines]]</div>

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