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{{Short description|Study of genetic variation within and between populations}}

'''Population structure''' in [[genetics]] refers to the presence of systematic differences in [[allele]] frequencies across populations due to factors such as [[geographical separation]], [[migration]], and [[genetic drift]]. Understanding population structure is crucial for interpreting genetic data, especially in the context of [[genome-wide association studies]] (GWAS) and [[evolutionary biology]].

==Overview==
Population structure arises when populations are subdivided into groups that are genetically distinct from one another. This can occur due to various factors, including historical separations, environmental barriers, and social structures that limit [[gene flow]]. The study of population structure helps in understanding the evolutionary history of populations and in identifying genetic variants associated with diseases.

==Factors Influencing Population Structure==

===Geographical Barriers===
Geographical barriers such as mountains, rivers, and oceans can limit the movement of individuals between populations, leading to genetic differentiation. Over time, isolated populations may accumulate genetic differences due to [[mutation]], [[genetic drift]], and [[natural selection]].

===Migration===
Migration introduces new genetic material into a population, which can alter allele frequencies and reduce genetic differentiation between populations. The extent of migration and the genetic makeup of migrants can significantly influence population structure.

===Genetic Drift===
[[File:Loss_of_heterozygosity_over_time_in_a_bottlenecking_population_with_label.png|Loss of heterozygosity over time in a bottlenecking population|thumb|right]]
Genetic drift is the random fluctuation of allele frequencies in a population. It has a more pronounced effect in small populations, where chance events can lead to significant changes in allele frequencies over time. Genetic drift can lead to the loss of genetic diversity, as illustrated in bottleneck events.

===Natural Selection===
Natural selection can lead to population structure when different environments favor different alleles. This can result in [[adaptive divergence]] between populations, where each population becomes better suited to its local environment.

==Methods of Studying Population Structure==

===Principal Component Analysis (PCA)===
[[File:Procrustes-transformed_PCA_plot_of_genetic_variation_of_Sub-Saharan_African_populations.png|Procrustes-transformed PCA plot of genetic variation of Sub-Saharan African populations|thumb|left]]
PCA is a statistical method used to reduce the dimensionality of genetic data and identify patterns of genetic variation. It is commonly used to visualize population structure by plotting individuals in a reduced space where clusters can indicate distinct populations.

===Structure Software===
The Structure software is a widely used tool for inferring population structure. It uses a model-based clustering method to assign individuals to populations based on their genotypes, estimating the number of populations (K) and the proportion of each individual's genome that comes from each population.

===F-statistics===
F-statistics, such as [[F_ST]], measure the degree of genetic differentiation between populations. High F_ST values indicate significant genetic differentiation, while low values suggest little differentiation.

==Implications of Population Structure==
Population structure has important implications for genetic research. It can confound the results of GWAS by creating spurious associations between genetic variants and traits. Correcting for population structure is essential to avoid false positives in genetic studies.

==Related pages==
* [[Genetic drift]]
* [[Gene flow]]
* [[Natural selection]]
* [[Genome-wide association study]]

[[Category:Population genetics]]

Population structure (genetics) - Revision history

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