https://wikimd.com/index.php?action=history&feed=atom&title=Plectasin Plectasin - Revision history 2026-04-21T21:33:29Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Plectasin&diff=6517703&oldid=prev Prab: CSV import 2025-03-17T23:05:33Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 23:05, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l27">Line 27:</td> <td colspan="2" class="diff-lineno">Line 27:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{pharmacology-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{pharmacology-stub}}</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">__NOINDEX__</ins></div></td></tr> </table> Prab https://wikimd.com/index.php?title=Plectasin&diff=6260236&oldid=prev Prab: CSV import 2025-02-10T21:41:56Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 21:41, 10 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l26">Line 26:</td> <td colspan="2" class="diff-lineno">Line 26:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{pharmacology-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{pharmacology-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table> Prab https://wikimd.com/index.php?title=Plectasin&diff=5375266&oldid=prev Prab: CSV import 2024-03-08T19:00:36Z <p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Plectasin&#039;&#039;&#039; is a [[defensin]]-like [[peptide]] that was first isolated from the [[fungus]] &#039;&#039;[[Pseudoplectania nigrella]]&#039;&#039;. It is a potent [[antibacterial]] agent, particularly against [[Gram-positive bacteria]], including [[methicillin-resistant Staphylococcus aureus]] (MRSA) and [[penicillin-resistant Streptococcus pneumoniae]] (PRSP).<br /> <br /> ==Structure==<br /> Plectasin is a small protein composed of 40 [[amino acids]]. It has a compact, globular structure, stabilized by three [[disulfide bond]]s. The structure of plectasin is similar to that of [[defensins]], a class of antimicrobial peptides found in the immune systems of animals and plants.<br /> <br /> ==Mechanism of Action==<br /> Plectasin exerts its antibacterial activity by binding to [[lipid II]], a key component in the synthesis of bacterial cell walls. This binding inhibits cell wall biosynthesis, leading to cell death. Unlike many other antibiotics, plectasin does not induce resistance in bacteria, making it a promising candidate for the development of new antibacterial drugs.<br /> <br /> ==Pharmacology==<br /> In preclinical studies, plectasin has shown potent activity against a range of Gram-positive bacteria, including MRSA and PRSP. It is also effective against bacteria that are resistant to other antibiotics. Plectasin is not toxic to human cells and has a low potential for inducing resistance.<br /> <br /> ==Clinical Development==<br /> Plectasin is currently in the early stages of clinical development. It has been tested in animal models of infection, where it has shown efficacy against MRSA and PRSP. Clinical trials in humans are planned.<br /> <br /> ==See Also==<br /> * [[Defensin]]<br /> * [[Antibiotic resistance]]<br /> * [[Methicillin-resistant Staphylococcus aureus]]<br /> * [[Penicillin-resistant Streptococcus pneumoniae]]<br /> <br /> ==References==<br /> &lt;references /&gt;<br /> <br /> [[Category:Antibiotics]]<br /> [[Category:Peptides]]<br /> [[Category:Pharmacology]]<br /> {{pharmacology-stub}}</div> Prab